Health Encyclopedia > Medications

mipomersen

Pronunciation: MYE poe mer sen

Brand: Kynamro

What is the most important information I should know about mipomersen?

Mipomersen is used together with a low-fat diet and other treatments to lower total cholesterol in people with homozygous familial hypercholesterolemia (an inherited type of high cholesterol).

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You should not use mipomersen if you have active liver disease or abnormal liver function tests.

Tell your doctor about all medicines you use. This includes prescription and over-the-counter medicines, vitamins, and herbal products.

Do not use mipomersen if you are pregnant or breast-feeding a baby. Stop using mipomersen and tell your doctor right away if you become pregnant.

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Mipomersen should be stored in a refrigerator, if possible. Allow the medicine to reach room temperature before giving an injection. Mipomersen may also be stored at room temperature for up to 14 days, protected from heat and light.

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Stop using mipomersen and call your doctor at once if you have fever, flu symptoms, upper stomach pain, loss of appetite, dark urine, jaundice (yellowing of the skin or eyes), or if you have swelling, bruising, or tenderness where an injection was given.

What is mipomersen?

Mipomersen is a cholesterol-lowering medication. It reduces blood levels of "bad" cholesterol, such as low-density lipoprotein (LDL), apolipoprotein-B (apo-B), or non-high-density lipoprotein (non-HDL).

Mipomersen is used together with a low-fat diet and other treatments to lower total cholesterol in people with homozygous familial hypercholesterolemia (an inherited type of high cholesterol).

It is not known whether mipomersen will lower your risk of heart disease.

Mipomersen is available only from a certified pharmacy under a special program called Kynamro REMS. Your doctor must be registered in the program in order to prescribe mipomersen for you.

Mipomersen may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using mipomersen?

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You should not use mipomersen if you are allergic to it, or if you have:

  • active liver disease; or
  • abnormal liver function tests.

To make sure mipomersen is safe for you, tell your doctor if you have:

  • cirrhosis or other liver disease;
  • kidney disease (or if you are on dialysis); or
  • if you drink alcohol.

Your doctor will perform blood tests to make sure you do not have conditions that would prevent you from safely using mipomersen.

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Do not use if you are pregnant. Use effective birth control during treatment. Stop using mipomersen and tell your doctor right away if you become pregnant.

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It is not known whether mipomersen passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

How is mipomersen given?

Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Mipomersen is injected under the skin. You may be shown how to use injections at home. Do not self inject this medicine if you do not understand how to give the injection and properly dispose of used needles and syringes.

Mipomersen is usually given once per week. Use this medicine on the same day each week, at the same time of day. Your care provider will show you the best places on your body to inject the medication.

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Mipomersen should be stored in a refrigerator, if possible.

Take a vial or prefilled syringe out of the refrigerator and allow it to reach room temperature before giving an injection. Do not heat the medicine before using.

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Mipomersen may also be stored at room temperature for up to 14 days. Keep the medicine in its original container and protect from heat or light.

Prepare your dose only when you are ready to give an injection. If you use any other injectable medication, do not mix it with mipomersen or inject it at the same time you inject mipomersen.

Do not use the medicine if it looks cloudy or has particles in it. Call your pharmacist for new medicine.

Each single-use vial (bottle) or prefilled syringe is for one use only. Throw away after one use, even if there is still some medicine left in it after injecting your dose.

Use a disposable needle only once, then throw away in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

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You may need frequent medical tests at your doctor's office to be sure this medication is not causing harmful effects. Your weekly treatments may be delayed based on the results of these tests.

Mipomersen is only part of a treatment program that may also include a special diet and other medications. Follow your doctor's instructions very closely.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if your next dose is less than 3 days away. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

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Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using mipomersen?

Avoid injecting mipomersen into skin areas that are swollen, irritated, sunburned, or affected by conditions such as psoriasis or a skin rash. Also avoid injecting into any skin area with a scar or tattoo.

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Avoid drinking more than 1 alcoholic drink per day. It may increase your risk of liver damage while you are taking mipomersen.

Avoid eating foods that are high in fat or cholesterol. Mipomersen will not be as effective in lowering your cholesterol if you do not follow a cholesterol lowering diet plan.

What are the possible side effects of mipomersen?

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Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

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Stop using mipomersen and call your doctor at once if you have:

  • fever, chills, body aches, flu symptoms, joint pain;
  • pain, swelling, redness, itching, bruising, or tenderness where an injection was given; or
  • nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects may include:

  • nausea;
  • headache; or
  • tired feeling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect mipomersen?

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with mipomersen, especially:

  • any other cholesterol-lowering medication;
  • acetaminophen (Tylenol);
  • isoniazid;
  • isotretinoin;
  • methotrexate;
  • tamoxifen;
  • valproic acid;
  • an antibiotic--erythromycin, doxycycline, minocycline, tetracycline;
  • birth control pills or hormone replacement therapy;
  • heart or blood pressure medication--amiodarone, methyldopa;
  • medicine to treat mental illness--chlorpromazine, fluphenazine, perphenazine, prochlorperazine, promethazine, thioridazine, trifluoperazine;
  • salicylates--aspirin, Nuprin Backache Caplet, Kaopectate, KneeRelief, Pamprin Cramp Formula, Pepto-Bismol, Tricosal, Trilisate, and others;
  • steroid medication (prednisone, and others);
  • a sulfa drug; or
  • thyroid medications.

This list is not complete. Other drugs may interact with mipomersen, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

Your pharmacist can provide more information about mipomersen.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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