Health Encyclopedia > Medications

pegfilgrastim

Pronunciation: PEG fil GRAS tim

Brand: Neulasta

What is the most important information I should know about pegfilgrastim?

Multum donot

You should not use this medication if you are allergic to pegfilgrastim or filgrastim (Neupogen).

Before using pegfilgrastim, tell your doctor if you have sickle cell disorder, chronic myeloid leukemia, myelodysplasia (also called "preleukemia"), or if you are allergic to latex.

Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.

Multum donot

Pegfilgrastim is usually given once per chemotherapy cycle. This medication should not be given within 14 days before or 24 hours after you receive chemotherapy.

What is pegfilgrastim?

Pegfilgrastim is a man-made form of a protein that stimulates the growth of white blood cells in your body. White blood cells help your body fight against infection.

Pegfilgrastim is used to prevent neutropenia, a lack of certain white blood cells caused by receiving chemotherapy.

Pegfilgrastim may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using pegfilgrastim?

Multum donot

You should not use this medication if you are allergic to pegfilgrastim or filgrastim (Neupogen).

To make sure you can safely use pegfilgrastim, tell your doctor if you have any of these other conditions:

  • sickle cell disorder;
  • chronic myeloid leukemia;
  • myelodysplasia (also called "preleukemia"); or
  • if you are allergic to latex.
Multum nopreg

FDA pregnancy category C. It is not known whether pegfilgrastim will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

If you are pregnant, your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of pegfilgrastim on the baby.

Multum nobrfeed

It is not known whether pegfilgrastim passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use pegfilgrastim?

Pegfilgrastim is injected under the skin. You may be shown how to use injections at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.

This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Multum donot

Pegfilgrastim is usually given once per chemotherapy cycle. This medication should not be given within 14 days before or 24 hours after you receive chemotherapy.

Multum donot

Do not shake the prefilled syringe or you may ruin the medicine. Prepare your dose only when you are ready to give yourself an injection. Do not use the medication if it has changed colors or has particles in it. Call your doctor for a new prescription.

Each prefilled syringe is for one use only. Throw away after one use, even if there is still some medicine left in it after injecting your dose.

Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

To be sure this medication is helping your condition, your blood will need to be tested often. This will help your doctor determine how long to treat you with pegfilgrastim. Visit your doctor regularly.

Multum refig

Store this medication in the refrigerator, do not freeze. Protect from light and do not shake. Take the medicine out and allow it to reach room temperature for 30 minutes before injecting your dose.

Throw away any unused syringes after the expiration date on the label has passed.

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose of pegfilgrastim.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using pegfilgrastim?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of pegfilgrastim?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Multum donot

Stop using pegfilgrastim and call your doctor at once if you have a serious side effect such as:

  • sudden or severe pain in your left upper stomach spreading up to your shoulder;
  • severe dizziness, skin rash, or flushing (warmth, redness, or tingly feeling);
  • rapid breathing or feeling short of breath;
  • signs of infection such as fever, chills, sore throat, flu symptoms, easy bruising or bleeding (nosebleeds, bleeding gums), loss of appetite, nausea and vomiting, mouth sores, unusual weakness; or
  • bruising, swelling, pain, redness, or a hard lump where the injection was given.

Less serious side effects may include:

  • bone pain;
  • pain in your arms or legs; or
  • bruising, swelling, pain, redness, or a hard lump where the injection was given.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect pegfilgrastim?

There may be other drugs that can interact with pegfilgrastim. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your doctor or pharmacist can provide more information about pegfilgrastim.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2013 Cerner Multum, Inc. Version: 2.05. Revision date: 12/15/2010.

Your use of the content provided in this service indicates that you have read, understood and agree to the End-User License Agreement, which can be accessed by clicking on this link.

This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.

Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.

USNWR 2013-2014Magnet Hospital RecognitionConsumer Choice2014 Best DoctorsJoint Commission Report

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.