Raloxifene is taken in pill form every day. It can be taken
at any time during the day. It is used only for
Raloxifene is a selective estrogen
receptor modulator (SERM), which works like estrogen on bone. It also works
like an "anti-estrogen" on breast tissue and the uterus. As a result, raloxifene:
Raloxifene is used to prevent and
treat osteoporosis in women.
Raloxifene can also be used to help
prevent breast cancer in women who have a high risk for breast cancer.
Raloxifene may be a good choice for women who are considering medicines to prevent or treat osteoporosis and who also have a high risk for breast cancer.
Studies show that raloxifene increases bone density in the bones of the
spine and neck. This lowers the risk for broken spinal bones.1 Although raloxifene works much like estrogen, it may not be
as effective on bone.
Breast cancer. Among
high-risk women, raloxifene lowers the risk of breast cancer about as much as
All medicines have side effects. But many people don't feel the side effects, or they are able to deal with them. Ask your pharmacist about the side effects of each medicine you take. Side effects are also listed in the information that comes with your medicine.
Here are some important things to think about:
or other emergency services right away if you have:
Call your doctor right away if you have:
Common side effects of this medicine include:
See Drug Reference for a full list of side effects. (Drug
Reference is not available in all systems.)
Raloxifene raises your risk of
dangerous blood clots. So does bed rest. If you plan to have a surgery followed
by bed rest, talk to your doctor about ways to reduce the risk of blood clots
around the time of surgery.
Do not take raloxifene if you are taking certain
medicines, such as cholestyramine, to lower the amounts of cholesterol in your blood, or if you have liver disease.
Medicine is one of the many tools your doctor has to treat a health problem. Taking medicine as your doctor suggests will improve your health and may prevent future problems. If you don't take your medicines properly, you may be putting your health (and perhaps your life) at risk.
There are many reasons why people have trouble taking their medicine. But in most cases, there is something you can do. For suggestions on how to work around common problems, see the topic Taking Medicines as Prescribed.
Do not use this medicine if you are pregnant or planning to get pregnant. If you need to use this medicine, talk to your doctor about how you can prevent pregnancy.
There are not good studies that show whether or not the drug can harm a baby through breast-feeding. Talk to your doctor before taking this drug if you are breast-feeding.
Follow-up care is a key part of your treatment and safety. Be sure to make and go to all appointments, and call your doctor if you are having problems. It's also a good idea to know your test results and keep a list of the medicines you take.
Complete the new medication information form (PDF)(What is a PDF document?) to help you understand this medication.
Drugs for postmenopausal osteoporosis (2011).
Treatment Guidelines From The Medical Letter, 9(111): 67–74.
Vogel VG, et al. (2006). Effects of tamoxifen vs. raloxifene on the risk of developing invasive breast cancer and other disease outcomes: The NASBP study of tamoxifen and raloxifene (STAR) P-2 trial. JAMA, 295(23): 2727–2741.
November 6, 2012
Kathleen Romito, MD - Family Medicine
& Carla J. Herman, MD, MPH - Geriatric Medicine
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