Health Encyclopedia > Medications

regorafenib

Pronunciation: RE goe RAF e nib

Brand: Stivarga

What is the most important information I should know about regorafenib?

Multum donot

You should not use regorafenib if past use has caused severe bleeding, or if you have severe liver disease.

Multum calldoc

Regorafenib can harm your liver. Stop taking this medicine and call your doctor at once if you have nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).

Multum calldoc

Regorafenib can also cause severe bleeding. Call your doctor if you have blood in your urine or stools, abnormal vaginal bleeding, coughing up blood, or any bleeding that will not stop.

What is regorafenib?

Regorafenib is a cancer medication that interferes with the growth and spread of cancer cells in the body.

Regorafenib is used to treat colorectal cancer. It is also used to treat a rare type of tumor that can affect the esophagus, stomach, or intestines.

Regorafenib is usually given after other cancer medications have been tried without success.

Regorafenib may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking regorafenib?

Multum donot

You should not use regorafenib if past use has caused severe bleeding, or if you have severe liver disease.

To make sure regorafenib is safe for you, tell your doctor if you have:

  • liver disease;
  • heart disease, high blood pressure;
  • bleeding or blood clotting disorder such as hemophilia;
  • a history of recent heart attack or stroke (including "mini-stroke"); or
  • if you have recently had surgery.
Multum nopreg

FDA pregnancy category D. Do not use regorafenib if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

Use birth control to prevent pregnancy while you are receiving regorafenib, whether you are a man or a woman. Tell your doctor right away if a pregnancy occurs while either parent is taking regorafenib. Keep using birth control for at least 2 weeks after your treatment ends.

Multum nobrfeed

It is not known whether regorafenib passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How should I take regorafenib?

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Regorafenib is usually taken daily for 3 weeks followed by 1 week off the medicine. Your doctor will determine how many times you should repeat this treatment cycle.

Multum food

Regorafenib works best if you take it with a low-fat breakfast.

Multum nocrush

Do not crush, chew, or break a regorafenib tablet. Swallow it whole.

While using regorafenib, your blood pressure will need to be checked often. You may also need frequent blood tests at your doctor's office.

If you need surgery, tell the surgeon ahead of time that you are using regorafenib. You may need to stop using the medicine at least 2 weeks before your surgery. Follow your doctor's instructions.

Multum rt

Store at room temperature away from moisture and heat. Keep the tablets in their original container, along with the packet or canister of moisture-absorbing preservative.

Throw away any regorafenib tablets not used within 28 days after opening the bottle.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking regorafenib?

Grapefruit and grapefruit juice may interact with regorafenib and lead to potentially dangerous effects. Avoid the use of grapefruit products while taking regorafenib.

What are the possible side effects of regorafenib?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Multum calldoc

Stop using regorafenib and call your doctor at once if you have:

  • fever, chills, flu symptoms, mouth sores, severe or ongoing vomiting or diarrhea;
  • feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin;
  • blood in your urine or stools, coughing up blood or vomit that looks like coffee grounds;
  • heavy menstrual periods or abnormal vaginal bleeding;
  • any bleeding that will not stop;
  • chest pain and severe dizziness, fainting, feeling short of breath;
  • headache, confusion, change in mental status, vision loss, seizure (convulsions);
  • upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • dangerously high blood pressure (blurred vision, buzzing in your ears, anxiety, uneven heartbeats);
  • rash, blisters, oozing, or severe pain in the palms of your hands or the soles of your feet;
  • any wound that won't heal; or
  • severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common side effects may include:

  • diarrhea, stomach pain, weight loss;
  • hoarse voice; or
  • feeling weak or tired.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect regorafenib?

Many drugs can interact with regorafenib. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment with regorafenib, especially:

  • bosentan;
  • imatinib;
  • nefazodone;
  • St. John's wort;
  • an antibiotic--clarithromycin, nafcillin, rifabutin, rifampin, rifapentine, telithromycin;
  • antifungal medication--itraconazole, ketoconazole, posaconazole, voriconazole;
  • heart medication--nicardipine, quinidine;
  • hepatitis C medications--boceprevir, telaprevir;
  • HIV/AIDS medication--atazanavir, delavirdine, efavirenz, fosamprenavir, indinavir, nelfinavir, nevirapine, ritonavir, saquinavir; or
  • seizure medication--carbamazepine, fosphenytoin, oxcarbazepine, phenobarbital, phenytoin, primidone.

This list is not complete and many other drugs can interact with regorafenib. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

Where can I get more information?

Your pharmacist can provide more information about regorafenib.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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