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ritonavir

Pronunciation: rit OH na vir

Brand: Norvir

Norvir 100 mg

white, oval, imprinted with a DS 100

Image of Norvir 100 mg
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What is the most important information I should know about ritonavir?

Multum donot

Life-threatening side effects may occur if you take ritonavir with alfuzosin (Uroxatral), amiodarone (Cordarone, Pacerone), flecainide (Tambocor), propafenone (Rythmol), quinidine (Quin-G), voriconazole (Vfend), cisapride (Propulsid), pimozide (Orap), midazolam (Versed), triazolam (Halcion), St. John's wort, lovastatin (Mevacor, Altoprev, Advicor), simvastatin (Zocor, Simcor, Vytorin, Juvisync), sildenafil (Revatio, to treat pulmonary arterial hypertension), or an ergot medicine such as Ergomar, Cafergot, Ergotrate, D.H.E. 45, Migranal, Methergine.

There are many other medicines that can interact with ritonavir. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

HIV/AIDS is usually treated with a combination of drugs. Use all medications as directed by your doctor. Do not change your doses or medication schedule without your doctor's advice. Every person with HIV or AIDS should remain under the care of a doctor.

Multum donot

Taking this medication will not prevent you from passing HIV to other people. Avoid having unprotected sex or sharing razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

What is ritonavir?

Ritonavir is an antiviral medication that prevents human immunodeficiency virus (HIV) cells from multiplying in your body.

Ritonavir is used to treat HIV, which causes acquired immunodeficiency syndrome (AIDS). Ritonavir is not a cure for HIV or AIDS.

Ritonavir may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking ritonavir?

You should not take ritonavir if you are allergic to it.

Multum donot

Life-threatening side effects may occur if you take ritonavir with:

  • alfuzosin (Uroxatral);
  • amiodarone (Cordarone, Pacerone);
  • cisapride (Propulsid);
  • flecainide (Tambocor);
  • lovastatin (Mevacor, Altoprev, Advicor) or simvastatin (Zocor, Simcor, Vytorin, Juvisync);
  • midazolam (Versed) or triazolam (Halcion);
  • pimozide (Orap);
  • propafenone (Rythmol);
  • quinidine (Quin-G);
  • sildenafil (Revatio) when used to treat pulmonary arterial hypertension (PAH);
  • St. John's wort;
  • voriconazole (Vfend); or
  • ergot medicine such as ergotamine (Ergomar, Cafergot, Migergot), dihydroergotamine (D.H.E. 45, Migranal), ergonovine (Ergotrate), or methylergonovine (Methergine).

To make sure you can safely take ritonavir, tell your doctor if you have any of these other conditions:

  • liver disease (especially hepatitis B or C);
  • diabetes;
  • heart disease or heart rhythm disorder;
  • a bleeding disorder such as hemophilia; or
  • high cholesterol or triglycerides.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby, but HIV can be passed to your baby if you are not properly treated during pregnancy. Take all of your HIV medicines as directed to control your infection.

Multum nobrfeed

Women with HIV or AIDS should not breast feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.

Multum bcp

Ritonavir can make birth control pills or patches less effective. Ask your doctor about using a non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while taking ritonavir.

How should I take ritonavir?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Multum food

Ritonavir tablets must be taken with meals. Ritonavir capsules or liquid should be taken with food if possible.

Multum nocrush

Do not crush, chew, or break a ritonavir tablet. Swallow it whole.

Multum shake

Shake ritonavir liquid well just before you measure a dose. Measure the liquid with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Liquid ritonavir can be mixed with chocolate milk or a nutrition drink such as Ensure. Drink the mixture within 1 hour after mixing.

Use ritonavir regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

HIV/AIDS is usually treated with a combination of drugs. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice. Every person with HIV or AIDS should remain under the care of a doctor.

Your blood will need to be tested on a regular basis. Your liver function may also need to be tested. Visit your doctor regularly.

Multum refig

Store ritonavir capsules in the refrigerator or at room temperature, away from heat or moisture. If you store the capsules at room temperature you must use them within 30 days. Protect from light.

Multum rt

Store ritonavir tablets at room temperature away from heat or moisture.

Multum rt

Store ritonavir liquid at room temperature with the cap tightly closed. Do not refrigerate.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of ritonavir oral liquid could be fatal to a child.

What should I avoid while taking ritonavir?

If you also take didanosine (Videx), take it at least 2.5 hours before or after you take ritonavir.

Multum noalcohol

Ritonavir capsules and oral liquid contain alcohol. Avoid drinking alcoholic beverages while using this medicine, and do not take disulfiram (Antabuse) or you could have an alcohol reaction.

Multum donot

Taking this medication will not prevent you from passing HIV to other people. Avoid having unprotected sex or sharing razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

What are the possible side effects of ritonavir?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Multum donot

Stop taking ritonavir and call your doctor at once if you have any of these serious side effects:

  • slow or uneven heart rate, feeling like you might pass out;
  • increased urination or extreme thirst;
  • easy bruising or bleeding (nosebleed or bleeding gums);
  • signs of a new infection, such as fever or chills, cough, or flu symptoms;
  • rapid heart rate, increased sweating, tremors in your hands, anxiety, feeling irritable, sleep problems (insomnia);
  • diarrhea, unexplained weight loss, menstrual changes, impotence, loss of interest in sex;
  • swelling in your neck or throat (enlarged thyroid);
  • muscle weakness, tired feeling, trouble speaking or swallowing, joint or muscle pain, feeling short of breath;
  • weakness or prickly feeling in your fingers or toes;
  • problems with walking, breathing, speech, swallowing, or eye movement;
  • severe lower back pain, loss of bladder or bowel control;
  • severe pain in your upper stomach spreading to your back, vomiting, fast heart rate;
  • nausea, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
  • severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Less serious side effects may include:

  • mild nausea, vomiting;
  • numbness or tingling, especially around your mouth;
  • headache, mood changes; or
  • changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect ritonavir?

Multum donot

Many drugs can interact with ritonavir. Below is just a partial list. Tell your doctor if you are using:

  • ADHD medication;
  • atorvastatin (Lipitor, Caduet) or rosuvastatin (Crestor);
  • atovaquone (Malarone, Mepron) or quinine (Qualaquin);
  • salmeterol (Advair, Serevent), theophylline (Elixophyllin, Theo-24, Uniphyl);
  • steroids (oral, nasal, inhalation, or injectable)
  • an antibiotic or antifungal medication;
  • an antidepressant;
  • any other HIV/AIDS medications;
  • heart or blood pressure medication;
  • insulin or diabetes medication you take by mouth;
  • medications to treat leukemia;
  • medicines used to prevent organ transplant rejection;
  • medicine to treat a psychiatric disorder;
  • erectile dysfunction medication (Viagra, Cialis, Levitra);
  • narcotic pain medication such as fentanyl (Abstral, Actiq, Fentora, Duragesic, Lazanda, Onsolis);
  • a sedative (such as BuSpar, Tranxene, Prosom, Dalmane); or
  • seizure medication.
Multum donot

This list is not complete and many other medicines can interact with ritonavir. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

Where can I get more information?

Your pharmacist can provide more information about ritonavir.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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