Health Encyclopedia > Medications

simvastatin and sitagliptin

Pronunciation: SIM va stat in and SIT a GLIP tin

Brand: Juvisync

What is the most important information I should know about simvastatin and sitagliptin?

Simvastatin and sitagliptin is a combination medicine for people with type 2 diabetes who also have high cholesterol.

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You should not use this medicine if you have liver disease or severe kidney disease. Do not use this medication if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

Do not use this medicine if you are pregnant or breast-feeding.

There are many other drugs that should not be used together with simvastatin and sitagliptin. Tell your doctor about all other medicines you use. Do not consume grapefruit products while taking this medication.

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Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine. Also call your doctor if you have severe pain in your upper stomach spreading to your back.

What is simvastatin and sitagliptin?

Simvastatin is an HMG CoA reductase inhibitor, or "statin." Simvastatin reduces levels of "bad" cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of "good" cholesterol (high-density lipoprotein, or HDL).

Sitagliptin is an oral diabetes medicine that helps control blood sugar levels. It works by regulating the levels of insulin your body produces after eating.

Simvastatin and sitagliptin is a combination medicine for people with type 2 diabetes who also have high cholesterol or triglycerides (types of fat) in the blood. This medication is not for treating type 1 diabetes.

Simvastatin and sitagliptin is also used to lower the risk of stroke, heart attack, and other heart complications in people with diabetes, coronary heart disease, or other risk factors.

Simvastatin and sitagliptin may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking simvastatin and sitagliptin?

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You should not use this medicine if you are allergic to simvastatin or sitagliptin, if you have liver disease or severe kidney disease, or if you are pregnant or breast-feeding.

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Do not use this medication if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

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In rare cases, simvastatin and sitagliptin can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.

Some medicines can cause unwanted or dangerous effects when used with simvastatin and sitagliptin. Your doctor may need to change your treatment plan if you use any of the following drugs:

  • cyclosporine;
  • danazol;
  • gemfibrozil;
  • nefazodone;
  • the antibiotics clarithromycin, erythromycin, or telithromycin;
  • the antifungal medications itraconazole, ketoconazole, posaconazole, or voriconazole;
  • the hepatitis C medications boceprevir or telaprevir; or
  • the HIV/AIDS medications atazanavir, darunavir, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir, or tipranavir.

Before you start taking simvastatin and sitagliptin, tell your doctor if you are already using any of these other medicines:

  • amiodarone or dronedarone;
  • amlodipine;
  • diltiazem;
  • ranolazine; or
  • verapamil.

To make sure simvastatin and sitagliptin is safe for you, tell your doctor if you have:

  • a history of liver or kidney disease;
  • a history of pancreatitis;
  • a history of gallstones;
  • underactive thyroid; or
  • a history of alcoholism.
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FDA pregnancy category X. This medication can harm an unborn baby or cause birth defects. Do not take simvastatin and sitagliptin if you are pregnant. Stop taking the medicine and tell your doctor right away if you become pregnant. Use effective birth control to avoid pregnancy while you are taking simvastatin and sitagliptin.

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It is not known whether this medication passes into breast milk or if it could harm a nursing baby. Do not breast-feed while you are taking simvastatin and sitagliptin.

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Do not give this medication to anyone under 18 years old without medical advice.

How should I take simvastatin and sitagliptin?

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Simvastatin and sitagliptin is usually taken once daily in the evening.

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Do not crush, chew, or break the tablet. Swallow it whole.

Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office.

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Check your blood sugar carefully during times of stress, travel, illness, surgery or medical emergency, vigorous exercise, or if you drink alcohol or skip meals. These things can affect your glucose levels and your dose needs may also change. Do not change your medication dose or schedule without your doctor's advice.

Simvastatin and sitagliptin is only part of a complete program of treatment that also includes diet, exercise, weight control, and possibly other medications. Follow your diet, medication, and exercise routines very closely.

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Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

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Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking simvastatin and sitagliptin?

Grapefruit and grapefruit juice may interact with simvastatin and lead to potentially dangerous effects. Do not consume grapefruit products while taking this medication.

Avoid eating foods that are high in fat or cholesterol. Simvastatin will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan.

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Avoid drinking alcohol. It can lower your blood sugar and may increase your risk of liver damage while taking this medicine.

What are the possible side effects of simvastatin and sitagliptin?

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Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

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In rare cases, simvastatin and sitagliptin can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.

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Stop using simvastatin and sitagliptin and call your doctor at once if you have:

  • confusion, memory problems;
  • swelling, weight gain, urinating less than usual or not at all;
  • severe pain in your upper stomach spreading to your back, nausea and vomiting, loss of appetite, fast heart rate;
  • increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss;
  • itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
  • severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common side effects may include:

  • cold symptoms such as stuffy nose, sneezing, sore throat;
  • constipation, mild stomach pain, mild nausea;
  • dizziness, tingly feeling;
  • depression, memory problems, sleep problems (insomnia);
  • headache, joint pain; or
  • trouble having an erection.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect simvastatin and sitagliptin?

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with simvastatin and sitagliptin, especially:

  • colchicine;
  • digoxin, digitalis;
  • a blood thinner such as warfarin, Coumadin;
  • fenofibric acid or fenofibrate;
  • medicines that contain niacin; or
  • any other "statin" medication such as atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, or other medication that contains simvastatin.

Although sitagliptin is not as likely to cause hypoglycemia (low blood sugar) as some other oral diabetes medications, tell your doctor if you are taking any other drugs that can potentially lower blood sugar, such as:

  • probenecid;
  • aspirin or other salicylates (including Pepto-Bismol);
  • sulfa drugs (Bactrim, Septra, Sulfatrim, SMX-TMP, and others);
  • a monoamine oxidase inhibitor (MAOI);
  • a beta-blocker; or
  • insulin, or an oral diabetes medication such as glipizide, glimepiride, glyburide, and others.

These lists are not complete and many other medicines can increase or decrease the effects of simvastatin and sitagliptin on lowering your blood sugar. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

Where can I get more information?

Your pharmacist can provide more information about simvastatin and sitagliptin.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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