Health Encyclopedia > Medications

ticarcillin and clavulanate potassium (injection)

Pronunciation: TYE kar SIL in KLAV ue la nate poe TAS ee um

Brand: Timentin

What is the most important information I should know about ticarcillin and clavulanate potassium?

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Do not use this medication if you are allergic to clavulanate potassium, ticarcillin or to any other penicillin antibiotic, such as amoxicillin (Amoxil, Augmentin), ampicillin (Omnipen, Principen), carbenicillin (Geocillin), dicloxacillin (Dycill, Dynapen), oxacillin (Bactocill), penicillin (Beepen-VK, Ledercillin VK, Pen-V, Pen-Vee K, Pfizerpen, V-Cillin K, Veetids), and others.

Before using ticarcillin and clavulanate potassium tell your doctor if you are allergic to cephalosporins such as Ceclor, Ceftin, Duricef, Keflex, and others, or if you have kidney disease, a bleeding or blood clotting disorder, low levels of potassium in your blood, a history of any type of allergy, or if you are on a salt-restricted diet.

Use this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Ticarcillin and clavulanate potassium will not treat a viral infection such as the common cold or flu.

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Ticarcillin and clavulanate potassium can make birth control pills less effective. Use a second non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while using ticarcillin and clavulanate potassium.

What is ticarcillin and clavulanate potassium?

Ticarcillin is an antibiotic in a group of drugs called penicillins. Ticarcillin fights bacteria in the body.

Clavulanate potassium is a form of clavulanic acid, which is similar to penicillin. Clavulanate potassium fights bacteria that is often resistant to penicillins and other antibiotics.

The combination of ticarcillin and clavulanate potassium is used to treat many different infections caused by bacteria, such as urinary tract infections, bone and joint infections, severe vaginal infections, stomach infections, and skin infections.

Ticarcillin and clavulanate potassium may also be used for other purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using ticarcillin and clavulanate potassium?

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Do not use this medication if you are allergic to clavulanate potassium, ticarcillin, or to any other penicillin antibiotic, such as:

  • amoxicillin (Amoxil, Augmentin);
  • ampicillin (Omnipen, Principen);
  • carbenicillin (Geocillin);
  • dicloxacillin (Dycill, Dynapen);
  • oxacillin (Bactocill); or
  • penicillin (Beepen-VK, Ledercillin VK, Pen-V, Pen-Vee K, Pfizerpen, V-Cillin K, Veetids, and others).

If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication. Before using ticarcillin and clavulanate potassium, tell your doctor if you are allergic to any drugs (especially cephalosporins such as Ceclor, Ceftin, Duricef, Keflex, and others), or if you have:

  • kidney disease;
  • a bleeding or blood clotting disorder;
  • an electrolyte imbalance such as low levels of potassium in your blood;
  • a history of any type of allergy; or
  • if you are on a salt-restricted diet.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

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Ticarcillin and clavulanate potassium can make birth control pills less effective. Use a second non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while using ticarcillin and clavulanate potassium.

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It is not known whether ticarcillin and clavulanate potassium passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use ticarcillin and clavulanate potassium?

Use this medication exactly as it was prescribed for you. Do not use the medication in larger amounts, or use it for longer than recommended by your doctor. Follow the instructions on your prescription label.

Ticarcillin and clavulanate potassium is given as an injection through a needle placed into a vein. Your doctor, nurse, or other healthcare provider will give you this injection. You may be shown how to use your medicine at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of needles, IV tubing, and other items used in giving the medicine.

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Ticarcillin and clavulanate potassium must be mixed with a liquid (diluent) before injecting it. Do not mix the medicine until you are ready to give yourself an injection.

Ticarcillin and clavulanate potassium is usually given for 10 to 14 days, depending on the infection being treated. Follow your doctor's instructions.

Use each disposable needle only one time. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your kidney or liver function may also need to be tested. Do not miss any scheduled visits to your doctor.

Use this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Ticarcillin and clavulanate potassium will not treat a viral infection such as the common cold or flu.

This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using ticarcillin and clavulanate potassium.

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Store unmixed ticarcillin and clavulanate potassium, and the liquid diluent, at cool room temperature.

What happens if I miss a dose?

Use the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and use the medicine at the next regularly scheduled time. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

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Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include drowsiness, hyperactivity, or seizure (convulsions).

What should I avoid while using ticarcillin and clavulanate potassium?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

What are the possible side effects of ticarcillin and clavulanate potassium?

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Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

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Call your doctor at once if you have any of these serious side effects:

  • diarrhea that is watery or bloody;
  • blood in your urine, feeling an urgent need to urinate, painful or difficult urination;
  • easy bruising or bleeding, unusual weakness;
  • dry mouth, increased thirst, confusion, increased urination, muscle pain or weakness, fast heart rate, feeling light-headed, fainting;
  • fever, chills, body aches, flu symptoms;
  • fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
  • chest pain; or
  • seizure (convulsions).

Less serious side effects may include:

  • mild diarrhea, gas, stomach pain;
  • nausea or vomiting;
  • joint or muscle pain;
  • headache;
  • skin rash or itching;
  • pain, swelling, or burning where the injection was given; or
  • vaginal yeast infection (itching or discharge).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect ticarcillin and clavulanate potassium?

There may be other drugs that can affect ticarcillin and clavulanate potassium. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your doctor or pharmacist can provide more information about ticarcillin and clavulanate.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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