Health Encyclopedia > Medications

treprostinil injection

Pronunciation: tre PROS ti nil

Brand: Remodulin

What is the most important information I should know about treprostinil injection?

Before using this medication, tell your doctor if you have low blood pressure, liver disease, or a bleeding or blood clotting disorder.

Treprostinil is given as an continuous (around-the-clock) injection using an infusion pump. The medicine enters the body through a catheter placed under your skin or into a vein. Your doctor, nurse, or pharmacist will give you specific instructions on how to use an infusion pump and inject your medicine.

Your doctor may want you to be in a hospital when you start using treprostinil. This is so you can be watched for any signs of serious side effects from the medicine.

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You will probably have to use this medicine for several months or years to control your condition and keep it from getting worse.

Use treprostinil regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely. Make sure you have a backup infusion pump and infusion sets available so as not to interrupt your treatment if one infusion pump stops working.

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Call your doctor if your symptoms do not improve or if they get worse.

What is treprostinil injection?

Treprostinil dilates (or widens) the arteries and decreases the amount of blood clotting platelets in your body. These effects lower blood pressure in the pulmonary artery that leads from the heart to the lungs.

Treprostinil is used to treat pulmonary arterial hypertension (PAH). It improves your ability to exercise and prevents your condition from getting worse.

Treprostinil may also be used for other purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using treprostinil injection?

If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication:

  • low blood pressure;
  • liver disease; or
  • bleeding or blood clotting disorder.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

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It is not known whether treprostinil passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How is treprostinil injection given?

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results.

Treprostinil is given as an continuous (around-the-clock) injection using an infusion pump. The medicine enters the body through a catheter placed under your skin or into a vein. Your doctor, nurse, or pharmacist will give you specific instructions on how to use an infusion pump and inject your medicine. Do not give yourself an injection if you do not understand these instructions. Call your doctor, nurse, or pharmacist for help with injection instructions.

Your doctor may want you to be in a hospital when you start using treprostinil. This is so you can be watched for any signs of serious side effects from the medicine.

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You will probably have to use this medicine for several months or years to control your condition and keep it from getting worse.

Use treprostinil regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely. Make sure you have a backup infusion pump and infusion sets available so as not to interrupt your treatment if one infusion pump stops working.

Do not use the medication if it has changed colors or has any particles in it. Call your doctor for a new prescription.

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Store unopened vials (bottles) of treprostinil at room temperature away from moisture and heat. After the medicine has been placed into a syringe or pump, it should be given within 72 hours. If the medicine has been diluted (mixed with a liquid), you must use the medicine within 48 hours after mixing.

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Call your doctor if your symptoms do not improve or if they get worse.

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose of treprostinil.

What happens if I overdose?

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Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include warmth and redness or tingling under your skin, headache, feeling light-headed, fainting, nausea, vomiting, diarrhea, or seizure (convulsions).

What should I avoid while using treprostinil injection?

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Do not stop using treprostinil without first talking to your doctor. You may need to use less and less before you stop the medication completely.

What are the possible side effects of treprostinil injection?

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Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

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Call your doctor at once if you have any of these serious side effects:

  • new or worsening PAH symptoms such as feeling short of breath (even with mild exertion), tiredness, chest pain, and pale skin;
  • swelling in your hands or feet; or
  • feeling like you might pass out.

Less serious side effects may include:

  • pain, swelling, redness, bleeding, or a hard lump where your catheter is placed;
  • dizziness;
  • mild skin rash;
  • headache or jaw pain;
  • flushing (warmth, redness or tingling); or
  • diarrhea or nausea.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect treprostinil injection?

Tell your doctor about all other medicines you use, especially:

  • gemfibrozil (Lopid);
  • a blood thinner such as warfarin (Coumadin);
  • blood pressure medication such as a diuretic (water pill); or
  • medication used to prevent blood clots, such as alteplase (Activase), cilostazol (Pletal), clopidogrel (Plavix), dipyridamole (Persantine), ticlopidine (Ticlid), and urokinase (Abbokinase).

This list is not complete and other drugs may interact with treprostinil. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your doctor or pharmacist can provide more information about treprostinil injection.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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