Agitation


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Definition

Agitation is an unpleasant state of extreme arousal. An agitated person may feel stirred up, excited, tense, confused, or irritable.


Alternative Names

Restlessness


Considerations

Agitation can come on suddenly or over time. It can last for just a few minutes, or for weeks or even months. Pain, stress, and fever can all increase agitation.

Agitation by itself may not be a sign of a health problem. However, if other symptoms occur, it can be a sign of disease.

Agitation  with a change in alertness (altered consciousness) can be a sign of delirium. Delirium has a medical cause and should be checked by a health care provider right away.


Common Causes

There are many causes of agitation, some of which include:

  • Alcohol intoxication or withdrawal
  • Allergic reaction
  • Caffeine intoxication
  • Certain forms of heart, lung, liver, or kidney disease
  • Intoxication or withdrawal from drugs of abuse (such as cocaine, marijuana, hallucinogens, PCP, or opiates)
  • Hospitalization (older adults often have delirium while in the hospital)
  • Hyperthyroidism (overactive thyroid gland)
  • Infection (especially in elderly people)
  • Nicotine withdrawal
  • Poisoning (for example, carbon monoxide poisoning)
  • Theophylline, amphetamines, steroids, and certain other medicines
  • Trauma
  • Vitamin B6 deficiency

Agitation can occur with brain and mental health disorders, such as:

  • Anxiety
  • Dementia (such as Alzheimer's disease)
  • Depression
  • Mania
  • Schizophrenia

References

Park JM, Park L, Prager LM. Emergency psychiatry. In: Stern TA, Rosenbaum JF, Fava M, Biederman J, Rauch SL, eds. Massachusetts General Hospital Comprehensive Clinical Psychiatry. 1st ed. Philadelphia, Pa: Mosby Elsevier;2008:chap 87.

Rossi J, Swan MC, Isaacs ED. The violent or agitated patient. Emerg Med Clin North Am. 2010;28:235-256.

Inouye SK. Delirium or acute mental status change in the older patient. In: Goldman L, Schafer AI, eds. Cecil Medicine. 24th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 27.


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Review Date: 2/11/2012
Reviewed By: Linda Vorvick, MD, Medical Director and Director of Didactic Curriculum, MEDEX Northwest Division of Physician Assistant Studies, Department of Family Medicine, UW Medicine, School of Medicine, University of Washington; and David B. Merrill, MD, Assistant Clinical Professor of Psychiatry, Department of Psychiatry, Columbia University Medical Center, New York, NY. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M. Health Solutions, Ebix, Inc.
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Last Updated 4/17/2012
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