Health Encyclopedia > Medications

penicillin G benzathine

Pronunciation: PEN i SILL in G BEN za theen

Brand: Bicillin L-A

What is the most important information I should know about penicillin G benzathine?

Multum donot

You should not receive this medication if you are allergic to penicillin. Tell your doctor if you have ever had an allergic reaction to a cephalosporin antibiotic such as Ceftin, Cefzil, Omnicef, Keflex, and others.

Before you receive penicillin G benzathine, tell your doctor if you have asthma or a history of allergies, liver disease, kidney disease, or heart disease.

Be sure to receive all doses your doctor has prescribed. Your symptoms may get better before the infection is completely cleared.

After you have finished your treatment with penicillin G benzathine, your doctor may want to do tests to make sure your infection has completely cleared up.

What is penicillin G benzathine?

Penicillin G benzathine is a slow-onset antibiotic that fights bacteria in your body.

Penicillin G benzathine is used to treat many different types of severe infections, including strep infections, rheumatic fever, and syphilis.

Penicillin G benzathine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before receiving penicillin G benzathine?

Multum donot

You should not receive this medication if you are allergic to penicillin. Tell your doctor if you have ever had an allergic reaction to a cephalosporin antibiotic such as cefdinir (Omnicef), cefprozil (Cefzil), cefuroxime (Ceftin), cephalexin (Keflex), and others.

To make sure penicillin G benzathine is safe for you, tell your doctor if you have:

  • asthma or a history of allergies;
  • liver disease;
  • kidney disease; or
  • heart disease.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

Multum nobrfeed

Penicillin G benzathine can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How is penicillin G benzathine given?

Penicillin G benzathine is injected into a muscle. A healthcare provider will give you this injection.

Penicillin G benzathine must be injected slowly into a muscle of the buttock.

Penicillin G benzathine is sometimes given only once or only for a few days until your symptoms clear up. Be sure to receive all doses your doctor has prescribed. Your symptoms may get better before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics.

After you have finished your treatment with penicillin G benzathine, your doctor may want to do tests to make sure your infection has completely cleared up.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your penicillin G benzathine injection.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while receiving penicillin G benzathine?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop taking penicillin G benzathine and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

What are the possible side effects of penicillin G benzathine?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Multum calldoc

Call your doctor at once if you have:

  • diarrhea that is watery or bloody;
  • fever, swollen glands, rash or itching, muscle or joint pain, night sweats, general ill feeling;
  • a feeling like you might pass out;
  • skin rash with bruising, severe tingling, numbness, pain, muscle weakness;
  • pale or yellowed skin, dark colored urine, weakness;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • little or no urinating;
  • fast or pounding heartbeats;
  • slow heart rate, weak pulse, fainting, slow breathing;
  • confusion, agitation, hallucinations, ringing in your ears, unusual thoughts or behavior;
  • seizure (convulsions);
  • pain, swelling, bruising, irritation, or skin changes where the injection was given; or
  • hardening of your skin in the thigh where the injection was given, trouble bending your knee.

Common side effects may include:

  • nausea, vomiting;
  • blurred vision;
  • dizziness; or
  • tired feeling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect penicillin G benzathine?

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with penicillin G benzathine, especially:

  • methotrexate;
  • probenecid;
  • birth control pills;
  • a blood thinner such as warfarin (Coumadin, Jantoven); or
  • a blood thinner such as warfarin, Coumadin; or
  • a tetracycline antibiotic--doxycycline, minocycline, tetracycline.

This list is not complete. Other drugs may interact with penicillin G benzathine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

Your doctor or pharmacist can provide more information about penicillin G benzathine.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2013 Cerner Multum, Inc. Version: 2.01. Revision date: 1/21/2013.

Your use of the content provided in this service indicates that you have read, understood and agree to the End-User License Agreement, which can be accessed by clicking on this link.

This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.

Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.

USNWR 2013-2014Magnet Hospital RecognitionConsumer Choice2014 Best DoctorsJoint Commission Report

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.