Health Encyclopedia > Medications

pentoxifylline

Pronunciation: pen tox I fi leen

Brand: TRENtal

Pentoxifylline 400 mg-APO

oval, white, imprinted with APO 033

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Pentoxifylline 400 mg-ESI

oblong, white, imprinted with P77, 511

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Pentoxifylline 400 mg-MYL

oblong, lavender, imprinted with MYLAN, 357

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Pentoxifylline 400 mg-TEV

oblong, white, imprinted with BVF, 0117

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Trental 400 mg

oblong, pink, imprinted with HOECHST, TRENTAL

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What is the most important information I should know about pentoxifylline?

Multum donot

You should not use this medication if you are allergic to pentoxifylline, or if you are allergic to caffeine or theophylline (Elixophyllin, Theo-24, Theo-Dur, Slo-Bid, Theochron, Theolair, Uniphyl, and others).

Multum emt

You also should not use pentoxifylline if you are breast-feeding a baby, or if you have recently had any type of bleeding in your brain or the retina of your eye.

Before you take pentoxifylline, tell your doctor if you have angina (chest pain), a heart rhythm disorder, high blood pressure, a stomach or intestinal ulcer, kidney disease, or if you have recently had surgery.

Tell your doctor about all other medicines you use, especially warfarin (Coumadin, Jantoven), theophylline (Elixophyllin, Theo-24, Theo-Dur, Slo-Bid, Theochron, Theolair, Uniphyl, and others), or blood pressure medication.

Multum food

Take pentoxifylline with food.

Multum emt

Stop taking this medication and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

What is pentoxifylline?

Pentoxifylline causes changes in your blood that help improve blood flow. This also helps your blood carry oxygen to your tissues and organs.

Pentoxifylline is used to improve blood flow and reduce certain symptoms of a condition called intermittent claudication (IN-ter-MIT-ent KLOD-ih-KAY-tion). Pentoxifylline is not a cure for this condition.

Pentoxifylline may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking pentoxifylline?

Multum donot

You should not use this medication if you are allergic to pentoxifylline, or if you are allergic to caffeine or theophylline (Elixophyllin, Theo-24, Theo-Dur, Slo-Bid, Theochron, Theolair, Uniphyl, and others).

Multum emt

You also should not use pentoxifylline if you have recently had any type of bleeding in your brain or the retina of your eyes.

To make sure you can safely take pentoxifylline, tell your doctor if you have other medical conditions, especially:

  • angina (chest pain);
  • a heart rhythm disorder;
  • high blood pressure (hypertension);
  • a stomach or intestinal ulcer;
  • kidney disease; or
  • if you have recently had surgery.
Multum nopreg

FDA pregnancy category C. It is not known whether pentoxifylline will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

Multum nobrfeed

Pentoxifylline can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using pentoxifylline.

How should I take pentoxifylline?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Multum food

Pentoxifylline is usually taken 3 times each day, with meals. Follow your doctor's instructions.

Multum nocrush

Do not crush, chew, or break an extended-release tablet. Swallow it whole. Breaking the pill may cause too much of the drug to be released at one time.

Multum finish

It may take up to 4 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve after 8 weeks of treatment.

Multum rt

Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe drowsiness, agitation, fever, flushing (warmth, redness, or tingly feeling), fainting, or seizure.

What should I avoid while taking pentoxifylline?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of pentoxifylline?

Multum emt

Stop taking this medication and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Multum donot

Call your doctor at once if you have a serious side effect such as:

  • chest pain,
  • pounding heartbeats or fluttering in your chest;
  • feeling like you might pass out;
  • red or pink urine;
  • bloody, black, or tarry stools; or
  • coughing up blood or vomit that looks like coffee grounds.

Less serious side effects may include:

  • dizziness, headache;
  • blurred vision;
  • flushing (warmth, redness, or tingly feeling);
  • gas, bloating, upset stomach; or
  • nausea, vomiting, diarrhea.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect pentoxifylline?

Tell your doctor about all other medicines you use, especially:

  • a blood thinner such as warfarin (Coumadin, Jantoven);
  • theophylline (Elixophyllin, Theo-24, Theo-Dur, Slo-Bid, Theochron, Theolair, Uniphyl, and others); or
  • blood pressure medication, especially nifedipine (Nifedical, Procardia) or captopril (Capoten, Capozide).

This list is not complete and other drugs may interact with pentoxifylline. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about pentoxifylline.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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