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Sickle Cell Disease

National Organization for Rare Disorders, Inc.

Important

It is possible that the main title of the report Sickle Cell Disease is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synonyms

  • Sickle Cell Anemia
  • Sickle Cell Trait

Disorder Subdivisions

  • Sickle Cell-Hemoglobin C Disease
  • Sickle Cell-Hemoglobin D Disease
  • Sickle Cell-Thalassemia Disease

General Discussion

Sickle cell disease is a rare inherited blood disorder. It is characterized by the presence of sickle or crescent shaped red blood cells (erythrocytes) in the bloodstream. These abnormally-shaped cells become rigid and lodge themselves in the very tiny blood vessels (capillaries) of the peripheral blood system (blood vessels outside of the heart). The capillaries become clogged, preventing the normal flow of oxygen to tissues. Common symptoms associated with sickle cell disease include chest pain, frequent infections, yellowing of the skin (jaundice), and low levels of circulating red blood cells (anemia). Sickle cell disease has several recognized forms including sickle cell anemia, sickle cell hemoglobin C disease and sickle cell thalassemia disease. Sickle cell disease is inherited as an autosomal recessive trait.

Resources

March of Dimes Birth Defects Foundation

1275 Mamaroneck Avenue

White Plains, NY 10605

Tel: (914)997-4488

Fax: (914)997-4763

Tel: (888)663-4637

Email: Askus@marchofdimes.com

Internet: http://www.marchofdimes.com



Piedmont Health Services and Sickle Cell Agency

1102 East Market Street

Greensboro, NC 27401

USA

Tel: (336)274-1507

Tel: (800)733-8297

Email: scdap@scdap.org

Internet: http://www.piedmonthealthservices.org/index.html



Cooley's Anemia Foundation, Inc.

330 7th Ave

Suite 900

New York, NY 10001

USA

Tel: (212)279-8090

Fax: (212)279-5999

Tel: (800)522-7222

Email: info@cooleysanemia.org

Internet: http://www.cooleysanemia.org



Sickle Cell Disease Association of America, Inc.

231 East Baltimore Street

Suite 800

Baltimore, MD 21202

USA

Tel: (410)528-1555

Fax: (410)528-1495

Tel: (800)421-8453

Email: scdaa@sicklecelldisease.org

Internet: http://www.sicklecelldisease.org



NIH/National Heart, Lung and Blood Institute

P.O. Box 30105

Bethesda, MD 20892-0105

Tel: (301)592-8573

Fax: (301)251-1223

Email: nhlbiinfo@rover.nhlbi.nih.gov

Internet: http://www.nhlbi.nih.gov/



Sickle Cell Association of Ontario

3199 Bathurst Street Suite 202

Toronto

Ontario, M6A 2B2

Canada

Tel: 4167892855

Fax: 4167891903

Email: sicklecell@look.ca

Internet: http://www.sicklecellontario.org/



Cochrane Cystic Fibrosis and Genetic Disorders Group

Institute of Child Health, University of Liverpool

Alder Hey Children's NHS Foundation Trust

Liverpool, L12 2 AP

United Kingdom

Tel: 441512525696

Email: nikkij@liverpool.ac.uk

Internet: http://cfgd.cochrane.org



Genetic and Rare Diseases (GARD) Information Center

PO Box 8126

Gaithersburg, MD 20898-8126

Tel: (301)251-4925

Fax: (301)251-4911

Tel: (888)205-2311

TDD: (888)205-3223

Internet: http://rarediseases.info.nih.gov/GARD/



Madisons Foundation

PO Box 241956

Los Angeles, CA 90024

Tel: (310)264-0826

Fax: (310)264-4766

Email: getinfo@madisonsfoundation.org

Internet: http://www.madisonsfoundation.org



Sickle Cell Awareness Group of Ontario

1280 Finch Ave W, Suite 517

Toronto

Ontario, M9M 2Z3

Canada

Tel: 4167454267

Fax: 9058300850

Email: info@sicklecellanemia.ca

Internet: http://sicklecellanemia.ca/index.php



For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

Last Updated:  4/9/2008

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