Microbiology & Immunology
Congratulations Dr. McIver
"I am lucky to have had the opportunity to work with the Department
of Microbiology & Immunology to complete my training as a scientist. When I
began, my knowledge of immunology was limited by assumptions derived from
clinical observations, and my basic science skills were incomplete. Throughout
my Ph.D. studies I was provided a welcoming environment where I have been able
to further my understanding of immunology and perfect my skills in
transitional research. As my project grew, so did the support. I am very
grateful to have had the opportunity to work with the many talented scientists
and mentors in the department."
A Great Place to
Learn - Grayson Receives Unsung Hero Award from Medical Students
Jason Grayson, PhD, an associate professor in the department
of microbiology and immunology, was presented with an “Unsung Hero” award on
April 10, 2017 by Medical Students (MS2020).
Dr. Grayson served as key instructor during Cellular and Subcellular Processes
(CSP), a year 1 medical school course which teaches biochemistry, immunology,
microbiology, genetics, and virology.
This course is led by co-course directors Greg Kucera, PhD and Lane
Smith, MD and is under the leadership of the Assistant Dean of Preclinical
Curriculum, Patrick Reynolds, MD and the Senior Associate Dean of Healthcare
Education, Mary Claire O’Brien, MD.
Students approached Dr. O’Brien during the course to extend
their thanks for Dr. Grayson’s dedication to education. Dr. Grayson, responsible mainly for the
immunology content in the CSP course, also received rave reviews on post-course
student evaluations. The students
commented about his use of a new instructional method called “boosts”
co-developed with an academic affairs instructional designer, Ms. Gia
Digiacobbe, which reinforced topics taught during lectures. Students commented that immunology is not
easy but Dr. Grayson’s presentation was very clear and well organized. The significant time outside of lecture spent
by Dr. Grayson to enhance student learning and experience was very much
Katlin Poladian, a MS 2020 medical student taking Dr.
Grayson’s course commented, “Dr. Grayson's patience is unparalleled when it
comes to answering questions regarding immunology. The time he sacrificed so
that my classmates and I could fully appreciate and understand the material did
not go unnoticed. We are so grateful for his engaging lectures and somewhat
unconventional teaching methods that made understanding things like Major
Histocompatibility Complexes and the function of plasma cells unforgettable.
Through his boost questions, office hours, and review sessions he instilled
confidence in us and our knowledge of immunology. Dr. Grayson is an unsung hero
Please join us in congratulating Dr. Jason Grayson on a job
well done and his contribution to making this a great place to learn and
Jerome McKay: Bootleg Scientist
The Department of Microbiology and Immunology has a vibrant
research program in host-pathogen interaction and immune regulation with
departmental faculty who are highly dedicated to graduate student training.
Research in the department is concentrated on
pathogens that are of substantial clinical importance including Streptococcus pneumoniae, Bordetella
pertussis, influenza virus, herpesvirus, and adenovirus. Many of these pose particular threats for
infants and young children.
Faculty with expertise in bacteriology and virology have
programs focused on elucidating the mechanisms utilized by pathogens to cause
disease, with the ultimate goal of understanding how we might better combat
these infectious agents. The programs of faculty focused on the immune response
seek to understand how B cells and T cells are regulated following infection with
the goal of promoting a more efficacious response.
An emerging collaborative area of focus in the department is
coinfection with multiple pathogens.
Here, faculty with expertise in bacteriology, virology, and immunology
are working together to understand the disease that is caused when multiple infections
are present, e.g. pneumococcus and influenza virus. Coinfections have been
appreciated as a clinically significant problem for a number of years, with one
of the most well known examples being the 1918 influenza pandemic.
Dr. Raj Deora is working to develop a novel vaccine against whooping cough.
Because vaccines are the most effective way to limit
disease, many faculty in the department have projects centered on the development
of improved vaccines. These include pneumococcus,
which is responsible for pneumonia, Bordetella,
the causative agent of whooping cough, and influenza. While vaccines are available for these
pathogens, new approaches are greatly needed. For example, the current vaccine for
B. pertussis is comprised of purified
proteins. While capable of eliciting an
immune response, this vaccine is only partially protective. As a result, whooping cough is on the
rise. Vaccines against pneumococcus are
also available, but immunity wanes over time and responses cannot be
effectively boosted, leaving individuals, especially the elderly, susceptible
to disease. Individuals at the other end of the age spectrum, young infants,
are also highly vulnerable to severe disease following infection. As a result of a weakened immune system,
vaccines work poorly in infants. Efforts
are ongoing to develop vaccines for influenza that will work in this at-risk
Dr. Martha Alexander-Miller is developing influenza vaccines that will work in young infants.
Faculty with expertise in immunology, cell damage and repair,
and virology are also investigating mechanisms of tumorigenesis and ways to
combat cancer. Faculty research is
focused on harnessing the power of the immune system to treat cancer is
broadening our understanding of how cancer-based vaccines, cancer-fighting
immune cells, and immunotherapy targeting checkpoint inhibitors might
effectively treat malignancies. Work on the
regulation of herpesviruses latency is laying the groundwork for understanding
herpesvirus-mediated oncogenesis. Finally,
faculty research on oncolytic adenoviruses and their mechanisms of inducing DNA
damage is leading to optimized oncolytic viruses for use as anti-cancer
therapies. Microbiology and Immunology faculty work in close collaboration with
fellow faculty members in our NCI-designated Comprehensive Cancer Center with
the goal of leveraging expertise to devise novel and effective approaches to
invite you to explore the research of our faculty in more detail, which is
presented in their individual research descriptions as well as in the video
links on this page. We also invite
prospective students to view the additional information about our graduate program.
Steve Mizel has created a vaccine against the bubonic plague.
"Words cannot begin to express the gratitude I have towards Dr. Alexander-Miller and the Department of Microbiology and Immunology for molding me into a thoughtful and thorough scientist. The training I received in the department was exceptional and best described as a group effort. Over the course of my training, the department felt less like a rigid academic structure and more like a family. Never once did I feel that I couldn’t approach any of the faculty, staff, or students with questions. Nor did I ever feel unwelcome just seeking an ear to bend regarding my own research project or life in general. I feel that this atmosphere goes above and beyond what is required to help shape the young minds of tomorrow, and my journey to attain my PhD was an exciting and positive venture as a result. To have such a concentrated group of intelligent, kind, and just people in a single department is truly a blessing. My experiences with my mentor and the faculty will stay with me for the rest of my life and have truly made me a better scientist and a better person." Lance Blevins