Gout Kidney Disease

Gout is a common disease caused by a buildup of uric acid in the bloodstream. The uric acid can precipitate in joints and cause gout.

Gout is more common in kidney disease because the body has difficulty getting rid of uric acid in the urine.

There is a special type of inherited gout and kidney disease studied by Wake Forest Medical School researcher Anthony Bleyer, M.D., M.S., a professor in the Section on Nephrology. This disease is called Uromodulin Kidney Disease.

What is Uromodulin Kidney Disease?
Uromodulin kidney disease is a condition caused by a mutation (mistake) in the gene that makes a protein called uromodulin. It leads to kidney failure and gout.

What are the signs of Uromodulin Kidney Disease?
1) Many family members develop kidney failure, with need for dialysis or kidney transplant sometime between age 30 and 60. An affected person has a 50% chance of passing the gene on to his children, so there are many family members with the disease.
2) While not all family members have gout, many develop gout at an unusually young age, often in the teenage years in boys and early twenties in girls.

What type of research is going on at Wake Forest in Uromodulin Kidney Disease?
Doctor Bleyer has been studying families with this disease for 15 years. He is trying to identify the characteristics of the disease to see if there are any potential treatments. According to Dr. Bleyer, “I am very interested in trying to find a cure for this disease. This is our primary goal.”

Doctor Bleyer is trying to recruit as many families as possible to study the disease. “The more families we have, the more we will find out.” At present, family members can participate by filling out questionnaires, sometimes undergoing blood tests, and sending records of their kidney function over time.

“I am also interested in helping any family with inherited kidney disease identify the cause of their kidney failure.”

If you are interested, please contact Dr. Bleyer at kidney@wakehealth.edu.

Also, see our website on this disorder at http://www.wakehealth.edu/nephrology/gout/

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Last Updated: 02-18-2014
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