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Medical Expert - Carol A. Shively, PhD

Area of Expertise: Pathology - Social Stress
Media Contact: Marguerite Beck
Media Office: 336-716-2415 Media Mobile: 336-480-8599
Patient Contact: Health On-Call® 1-800-446-2255
Area of Expertise: Psychiatry - Research
Media Contact: Marguerite Beck
Media Office: 336-716-2415 Media Mobile: 336-480-8599
Patient Contact: Health On-Call® 1-800-446-2255

Carol A. Shively, PhD

Professor, Pathology - Comparative Medicine

Shively investigates social stress effects on health, particularly women's health, including heart disease, obesity and depression, using non-human primate models. Her research focuses on how social stress, particularly the stress of low social status, increases the risk of coronary heart disease, depression, metabolic syndrome, obesity, and endometrial cancer. She uses non-invasive brain imaging to learn more about the brain mechanisms behind disease. She received the National Association for Women’s Health award for “Excellence in Research” and is listed in both Who’s Who of American Women and International Who’s Who. She has authored or co-authored more than 70 research papers.


women's health, stress, obesity, women's health-heart disease, obesity and depression, body mass index, adiposity, mental illness, social stress, depression, nonhuman primate models of stress and depression, behavioral neuroscience, cardiovascular disease, health disparities, social influences on health


Common Antidepressant Increased Coronary Atherosclerosis in Animal Model
A commonly prescribed antidepressant caused up to a six-fold increase in atherosclerosis plaque in the coronary arteries of non-human primates, according to a study by researchers at Wake Forest Baptist Medical Center. Coronary artery atherosclerosis is the primary cause of heart attacks.
Common Antidepressant May Change Brain Structures Differently in Depressed and Nondepressed Individuals

A commonly prescribed antidepressant may alter brain structures in depressed and non-depressed individuals in very different ways, according to new research at Wake Forest Baptist Medical Center.

Hippocampal Volume Loss in Depression Reflects Glial Loss
Depression has been associated with reduced volume of the hippocampus in magnetic resonance imaging studies in humans. A new study, led by Carol Shively, Ph.D., at Wake Forest Baptist Medical Center, just published in the journal Biological Psychiatry now clarifies the cellular basis of these volumetric changes, which have been unclear until now.

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