WFIRM Press Materials for 4-10-14 Lancet article


All material is EMBARGOED until 6:30 p.m. EDT on Thursday, April 10.


Read Wake Forest Institute for Regenerative Medicine’s News Release
http://www.wakehealth.edu/Research/WFIRM/News/News-Release-Lancet-Article.htm

NOTE: THE NEXT TWO LINKS ARE FOR JOURNALISTS ONLY

Read the Paper:  http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)60542-0/abstract

Read the Lancet’s News Release
http://press.thelancet.com/vaginalorgan.pdf

Read the Lancet’s Comment
http://press.thelancet.com/vaginatissueengineering.pdf

VIDEO for Download

Click on the image below to download high resolution video of Anthony Atala, M.D., director of the Wake Forest Institute for Regenerative Medicine, describing the research to engineer human vaginal organs.

Atala_study_video_thumbnail.jpg

Click on the image below to download high resolution B-roll video.

Atala_study_B-roll_video_thumbnail.jpg

 B-roll summary: Yuanyuan Zhang, M.D., Ph.D, assistant professor at the Wake Forest Institute for Regenerative Medicine, demonstrates the steps involved in engineering a vaginal organ:

  • A sheet of biocompatible material is moistened so that cells will adhere to the material.
  • The material is coated on one side with epithelial cells isolated from a small biopsy of the patient’s external genitals. (It takes three to five weeks to grow these cells.)
  • After placement in an incubator, cell media, which consists of nutrients to keep the cells alive, is added.
  • The other side of the scaffold is coated with smooth muscle cells taken from the patient’s biopsy and then placed in an incubator.
  • The scaffold is configured into a vaginal shape and then incubated for one week before implantation.

Click on the image below to download video of a patient who received a lab-engineered vaginal organ. (Video by Metropolitan Autonomous University. The patient does not want her name to be used and it is not provided.)

 Patient_Who_Received_Engineered_Vaginal_Organ_video_thumbnail.jpg

    Alternate download site if you experience difficulties:

    https://www.dropbox.com/sh/hnvvi2xzf9h9gyn/Qe18O-QyNI 
      

    STILL IMAGES for Download

    Click on the individual images below to download high-resolution photographs of Yuanyuan Zhang, M.D., Ph.D, assistant professor at the Wake Forest Institute for Regenerative Medicine, demonstrating the process to engineer a vaginal organ.

    RS040714-037_thumbnail.jpg
    The scaffold is made of a biodegradable material.

    RS040714-052_thumbnail.jpg
    Zhang prepares to coat one side of the scaffold with epithelial cells.

    RS040714-064_thumbnail.jpg
    The scaffold is placed in an incubator.

    RS040714-094_thumbnail.jpg

    RS040714-107_thumbnail.jpg
    The other side of the scaffold is coated with smooth muscle cells.

    RS040714-116_thumbnail.jpg
    A second period of incubation is required.

    RS040714-152_thumbnail.jpg
    The scaffold is configured into a vaginal shape.

    MRI_thumbnail.jpg
    Patient’s MRI image showing lab-engineered vaginal organ

    Atala1_thumbnail.jpg
    Anthony Atala, MD, Director, Wake Forest Institute for Regenerative Medicine

    Atala2_thumbnail.jpg
    Anthony Atala, MD, Director, Wake Forest Institute for Regenerative Medicine

     

     

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