Pain Mechanisms Lab
"Cultivating an open scientific community
that transforms pain treatment through innovative research."
Welcome From Dr. James C. Eisenach
The Pain Mechanisms Laboratory began with a collaboration between myself and Tony Yaksh nearly 25 years ago and has now grown to a vibrant group of investigators, post-doctoral fellows, students, and technicians. Throughout that time the core values of the laboratory have remained the same – to be a place of education and excited learning as we explore the translational science of pain and its treatment. We learn together through regular meetings, both formal and informal. My role as director of the laboratory is to foster these interactions, understand the career goals of all individuals in the laboratory, and assure that the experience of everyone here meets those goals.
This is a friendly place doing great science. We have brought 5 new non-opioid analgesic therapies from discovery to human clinical trials, including one which is FDA approved and the most commonly used non-narcotic spinal drug in the treatment of neuropathic pain. At nearly every meeting we discuss clinical needs and potential clinical application of our work, and most fellows interact with clinician investigators to test some aspects in humans of the work they perform in the lab.
- Dr. James C. Eisenach
In November 2013, the Pain Mechanisms Laboratory will move to its new state-of-the-art facility located at the Wake Forest Baptist Medical Center. The new facility includes more than 5,000 square feet of dedicated laboratory and office space. The new Pain Labs have been designed and built to support the operational philosophy that is the cornerstone of the Pain Lab's multidisciplinary research programs. The labs are open and spacious, with specific assignments to Principal Investigators. The division in the laboratory comes from the establishment of core facilities within the framework of the Pain Lab. While graduate students, postdocs, and research fellows are mentored by a primary PI, the approach to most programs is team-based. These new resources are vast and include molecular biochemistry, cell culture, DNA, radioactivity, histology, animal behavior and holding, perfusion, tissue culture, electrophysiology, and support cores. Graduate students, postdocs and fellows, and collaborators will share these resources. An abbreviated list of the major equipment includes light microscopy, fluorescent microscopy, organ bath, calcium imaging, patch clamp, imaging systems, lyophilizers, ultracentrifugation, blood analysis, cryogenic storage, shakers, ovens, centrifuges, incubators, biosafety hoods, walk-in fume hood, dialysis system, electroporator, bioanalyzer (electrophoresis, DNA, and flow cytometry), RT-PCR, microplate readers (fluorescence and UV/Vis), robotic microplate processors, gamma and beta counters, microtomes.