Allyn Howlett, PhD
Allyn Howlett, PhD
 | Allyn Howlett, PhD
Professor |
Dept. of Physiology & Pharmacology
Wake Forest School of Medicine
Medical Center Boulevard
Winston-Salem, North Carolina 27157-1083 |
Phone: 336-716-8545
Fax: 336-716-8501
Email: ahowlett@wakehealth.edu |
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Education
Postdoctoral Fellow, Department of Pharmacology, University of Virginia School of Medicine. 1976 - 1979
Rutgers State University; PhD, Pharmacology and Toxicology 1976
Pennsylvania State University; BS, Biochemistry, cum laude 1971
Research Area
Neuropharmacology, Signal transduction, Cell Biology, Cannabinoid Receptors, Endocannabinoids
Academic Activities
Graduate Program Recruiter
Phys-Pharm Outreach Committee
Post-doctoral Committee
NIH Study Sections
International Union Pharmacology Committee on Cannabinoid Receptors
Activities in Medical and Graduate Education
Teaching in the health science professions and graduate school in: endocrinology, pharmacology, physiology
Adjunct Faculty at WSSU
Brief Summary of Research
Dr. Howlett investigates cannabinoid and endocannabinoid compounds that stimulate the CB1 cannabinoid receptor and regulate signal transduction pathways in cultured neuronal cells. We study phosphorylation of the receptor as a means to direct signaling through specific G proteins, as well as the potential for drugs to direct the partnering with different G proteins leading to selection of certain signal transduction pathways (e.g., via adenylyl cyclase inhibition, MAPK activation, Ca2+ regulation, and NO production). The goal is identify drugs that target neurons in the brain that promote therapeutically beneficial actions (e.g., analgesia), but diminish the activity of neurons that produce untoward side effects (e.g., sedation, cognitive dysfunction).
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