Brian McCool, PhD

Brian McCool, PhD - Recent Publications

Silberman Y, Bajo M, Chappell AM, Christian DT, Cruz M, Diaz MR, Kash T, Lack AK, Messing RO, Siggins GR, Winder D, Roberto M, McCool BA, Weiner JL (2009) Neurobiological mechanisms contributing to alcohol-stress-anxiety interactions. Alcohol 43:509-519.

McCool BA, Chappell AM (2009) Early social isolation in male Long-Evans rats alters both appetitive and consummatory behaviors expressed during operant ethanol self-administration. Alcohol Clin Exp Res 33:273-282.

Lack AK, Christian DT, Diaz MR, McCool BA (2009) Chronic ethanol and withdrawal effects on kainate receptor-mediated excitatory neurotransmission in the rat basolateral amygdala. Alcohol 43:25-33.

Lack AK, Ariwodola OJ, Chappell AM, Weiner JL, McCool BA (2008) Ethanol inhibition of kainate receptor-mediated excitatory neurotransmission in the rat basolateral nucleus of the amygdala. Neuropharmacology 55:661-668.

McCool BA, Chappell A (2007) Strychnine and taurine modulation of amygdala-associated anxiety-like behavior is 'state' dependent. Behav Brain Res 178:70-81.

Lack AK, Diaz MR, Chappell A, DuBois DW, McCool BA (2007) Chronic ethanol and withdrawal differentially modulate pre- and postsynaptic function at glutamatergic synapses in rat basolateral amygdala. J Neurophysiol 98:3185-3196.

Anderson NJ, Daunais JB, Friedman DP, Grant KA, McCool BA (2007) Long-term ethanol self-administration by the nonhuman primate, Macaca fascicularis, decreases the benzodiazepine sensitivity of amygdala GABA(A) receptors. Alcohol Clin Exp Res 31:1061-1070.

DuBois DW, Perlegas A, Floyd DW, Weiner JL, McCool BA (2006) Distinct functional characteristics of the lateral/basolateral amygdala GABAergic system in C57BL/6J and DBA/2J mice. J Pharmacol Exp Ther 318:629-640.

Lack AK, Floyd DW, McCool BA (2005) Chronic ethanol ingestion modulates proanxiety factors expressed in rat central amygdala.  Alcohol. 36(2):83-90.

Floyd, D.W., Friedman, D.P., Daunais, J.B., Pierre, P.J., Grant, K.A., and McCool, B.A. (2004) Long-term ethanol ingestion alters GABAA receptors expressed in the basolateral amygdala of the Cynomolgus macaque, Macaca fascicularis.J. Pharmacol. Exper. Ther.311 (3): 1071-1079.

Farroni, J.S., and McCool, B.A. (2004) Subunit composition and expression system influence the agonist pharmacology of strychnine-sensitive glycine receptors.  BMC Pharmacol.4: 16 (

Floyd, D.W., Jung, K.-Y., and McCool, B.A. (2003) Chronic ethanol ingestion facilitates N-methyl-D-aspartate receptor function and expression in rat lateral/basolateral amygdala neurons.  J. Pharmacol. Exp. Ther.329:1020–1029.

McCool, B.A., Frye, G.D., Pulido, M.D., and Botting, S.K. (2003) Effects of chronic ethanol consumption on rat GABAA and strychnine-sensitive glycine receptors expressed by lateral/basolateral amygdala neuronsBrain Res.963: 165-177.

McCool, B.A.,and Farroni, J.S. (2001) Subunit composition of strychnine-sensitive glycine receptors in adult rat basolateral amygdala neuronsEur. J. Neurosci.14: 1082-1090.

McCool, B.A., and Farroni, J.S. (2001) A1 adenosine receptors inhibit multiple voltage-gated Ca2+ channel subtypes in acutely isolated rat basolateral amygdala neuronsBrit. J. Pharmacol.132: 879‑888.

McCool, B.A., and Botting, S.K. (2000) Characterization of strychnine-sensitive glycine receptors in acutely isolated adult rat basolateral amygdala neurons.  Brain Res.859: 341-351.

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