J. Charles Eldridge, PhD
J. Charles Eldridge, PhD
 | J. Charles Eldridge, PhD
Professor |
Dept. of Physiology & Pharmacology
Wake Forest School of Medicine
Medical Center Boulevard
Winston-Salem, North Carolina 27157-1083 |
Phone: 336-716-8570
Fax: 336-716-8501
Email: eldridge@wakehealth.edu |
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Education
PhD (1971) - Medical College of Georgia, Augusta, GA (Endocrinology)
MS (1967) - Northern Illinois University, DeKalb, IL (Physiology)
BA (1965) - North Central College, Naperville, IL (Biology/Chemistry)
Research Area
Reproductive endocrinology, endocrine toxicology, steroid hormone biochemistry and receptor interaction
Academic Activities
Consultant in reproductive and endocrine toxicology to the US EPA, the Science Advisory Panel, governmental and industrial research, service to peer-reviewed journals, and membership on the WFU general radiation safety committee.
Activities in Medical and Graduate Education
Medical: endocrine physiology-pharmacology, small group case-centered learning, Core Teaching Faculty
Graduate: endocrine physiology-pharmacology, graduate student courses on scientific professionalism & integrity, bioethics & social responsibility.
Brief Summary of Research
Our laboratory currently focuses on endocrine toxicology and particularly “endocrine disruptors”, chemicals that may imitate, inhibit or otherwise modulate hormones and the endocrine system. For many years we have investigated the actions of agricultural herbicides, particularly the mechanisms by which these chemicals disrupt estrous cycling in rodent models used for toxicology screens.
We are also using our experience with steroid receptors to uncover details of competitive binding properties of environmentally sensitive chemicals with the estrogen receptor, particularly varying strategies that chemicals use to associate with receptor binding.
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