Mei-Chuan Ko, PhD

Mei-Chuan Ko, PhD - Selected Publications

Published Articles in PubMed  

NIDA Science Spotlight
Pain relief without risk of addiction or overdose?  

Scientists deliver opioid-like pain relief without addiction risk

Ding H, Czoty PW, Kiguchi N, Cami-Kobeci G, Sukhtankar DD, Nader MA, Husbands SM, Ko MC. (2016)
A novel orvinol analog, BU08028, as a safe opioid analgesic without abuse liability in primates. Proceedings of the National Academy of Sciences of the United States of America 113(37):E5511-E5518. PMID: 27573832
doi: 10.1073/pnas.1605295113  

Kiguchi N, Ding H, Ko MC. (2016)
Central N/OFQ-NOP Receptor System in Pain Modulation. Advances in Pharmacology 75:217-243. PMID: 26920014
doi: 10.1016/bs.apha.2015.10.001  

Kiguchi N, Sukhtankar DD, Ding H, Tanaka KI, Kishioka S, Peters CM, Ko MC. (2016)
Spinal functions of B-type natriuretic peptide, gastrin-releasing peptide, and their cognate receptors for regulating itch in mice. Journal of Pharmacology & Experimental Therapeutics 356(3):596-603. PMID: 26669425  

Rizzi A, Sukhtankar DD, Ding H, Hayashida K, Ruzza C, Guerrini R, Calo’ G, Ko MC. (2015)
Spinal antinociceptive effects of the novel NOP receptor agonist PWT2-nociceptin/orphanin FQ in mice and monkeys. British Journal of Pharmacology 172(14):3661-3670. PMID: 25828800  

Lee H, Ko MC. (2015)
Distinct functions of opioid-related peptides and gastrin-releasing peptide in regulating itch and pain in the spinal cord of primates. Scientific Reports 5:11676. PMID: 26119696  

Ding H, Hayashida K, Suto T, Sukhtankar DD, Kimura M, Mendenhall V, Ko MC. (2015)
Supraspinal actions of nociceptin/orphanin FQ, morphine and substance P in regulating pain and itch in non-human primates. British Journal of Pharmacology 172(13):3302-3312. PMID: 25752320  

Ko MC. (2015)
Neuraxial Opioid-Induced Itch and Its Pharmacological Antagonism. Handbook of Experimental Pharmacology 226: 315-335. PMID: 25861787
doi: 10.1007/978-3-662-44605-8_17  

Schröder W. Lambert DG. Ko MC. Koch T. (2014)
Functional plasticity of the N/OFQ-NOP receptor system determines analgesic properties of NOP receptor agonists. British Journal of Pharmacology 171(16):3777-3800. PMID: 24762001  

Sukhtankar DD. Lee H. Rice KC. Ko MC. (2014)
Differential effects of opioid-related ligands and NSAIDs in nonhuman primate models of acute and inflammatory pain. Psychopharmacology (Berl) 231(7):1377-1387. PMID: 24217900  

Molinari S. Camarda V. Rizzi A. Marzola G. Salvadori S. Marzola E. Molinari P. McDonald J. Ko MC. Lambert DG. Calo’ G. Guerrini R. (2013)
[Dmt1]N/OFQ(1-13)-NH2, a potent nociceptin/orphanin FQ and opioid receptor universal agonist. British Journal of Pharmacology 168(1):151-162. PMID: 22827708  

Sukhtankar DD. Ko MC. (2013)
Physiological function of gastrin-releasing peptide and neuromedin B receptors in regulating itch scratching behavior in the spinal cord of mice. PLoS ONE 8(6):e67422. PMID: 23826298  

Sukhtankar DD. Zaveri NT. Husbands SM. Ko MC. (2013)
m-opioid receptor ligands in mouse models of neuropathic and inflammatory pain. Journal of Pharmacology & Experimental Therapeutics 346(1):11-22. PMID: 23652222  

Lin AP. Ko MC. (2013)
The therapeutic potential of nociceptin/orphanin FQ receptor agonists as analgesics without abuse liability. ACS Chemical Neuroscience 4(2):214-224. PMID: 23421672  

Ko MC. Husbands SM. (2013)
Research and Development of Opioid-Related Ligands (Editors: MC Ko & SM Husbands). ACS Symposium Series, volume 1131, American Chemical Society/ACS Publications, Washington DC, USA (Distributed in print by Oxford University Press, Inc.). ISBN13: 978-0841227828.
doi: 10.1021/bk-2013-1131

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