Paul W. Czoty, PhD
Paul W. Czoty, PhD - Research Interests
- Characterizing the genetic, environmental and neurobiological factors that influence sensitivity to the abuse-related effects of cocaine and alcohol
- Understanding long-term changes in the brain and in behavior that occur during cocaine and alcohol self-administration and during abstinence
- Defining the pharmacological properties that characterize an effective medication for cocaine and alcohol abuse disorders
Two nonhuman primate models of drug abuse, self-administration and discrimination, are employed in the laboratory in an effort to better understand the behavioral and neurochemical effects of abused drugs, with a focus on cocaine and alcohol. In self-administration studies, rhesus or cynomolgus monkeys are surgically prepared with chronically-indwelling intravenous catheters and are trained to make an operant response that results in the delivery of cocaine and alcohol. In drug discrimination studies, monkeys are reinforced for different responses in the presence vs. absence of cocaine and alcohol.
The noninvasive imaging procedure of Positron Emission Tomography (PET) is used to study changes in dopamine and serotonin receptors and transporters as a consequence of cocaine exposure and abstinence. In addition, studies are underway to adapt MRI-based imaging procedures, including diffusion tensor imaging (DTI) and magnetic resonance spectroscopy (MRS), for use in monkeys.
Socially housed monkeys
Studies in this laboratory investigate the effects of chronic social stress and enrichment on dopamine function and on the behavioral effects of cocaine in group-housed monkeys.