Thomas Beveridge, PhD

Thomas Beveridge, PhD - Research Interests

beveridge


Research Interests


For the past few years my research has focused on identifying the substrates of neurobiological responses to cocaine in the brain using predominantly in vitro imaging techniques.  Chronic cocaine exposure has been shown to lead to functional deficits and structural disruptions within the brains of cocaine addicts.  To date we have concentrated on the catecholamine system, in accordance with where many of these deficits have been found.  Data now, however, suggests that the glutamate system also has a critical role in mediating the effects of cocaine, especially the long term neuroplastic changes that accompany cocaine use and abstinence.

More recently my work has focused on the neurobiology of methamphetamine addiction and the use of rodent methamphetamine self-administration models.  A major avenue of my research is determining the effectiveness of novel cocaine and methamphetamine addiction medications, using both a 'top down' and bottom up' approach.  In this manner we can assess which potential new candidate therapies may be useful for further development in the treatment of cocaine and methamphetamine addiction.  Recently, I have begun evaluating the cardiovascular damage induced by methamphetamine self-administration, and whether anti-hypertensive agents can reverse these deleterious effects.

Techniques

2-[14C]deoxyglucose (2DG) method of visualizing neuronal activity
Receptor autoradiography
Self-administration models
Total protein isolation and membrane fractionation
Western blot and in situ hybridization analysis

Ongoing Grant Support
 
P50 DA06634 (PD: Steven Childers)  
04/01/10 – 03/31/15 
National Institute of Drug Abuse  
Tissue Core Role: Principal Investigator
Project 2 Role: Co-Investigator
‘Center for the Neurobiology of Addiction Treatment’

R01 DA09085 (PI: Linda Porrino)  
07/01/95 – 6/30/11 
National Institute of Drug Abuse  
Role: Co-Investigator
‘Neurobiological Correlates of Cocaine Abuse in Primates’

 
Completed Research Support

R03 DA026590 (PI: Thomas Beveridge) 
07/01/09-01/31/12 
National Institute of Drug Abuse  
Role: Principal Investigator
‘Effect of Cocaine Self-Administration on Metabotropic Glutamate Systems’

P50 DA06634 (PD: Steven Childers)  
10/01/06 – 09/30/08
CNIDA Pilot Grant    
Role: Principal Investigator
 ‘Assessment of Changes in Homer Protein in Nonhuman Primate Striatum Following Chronic Cocaine Self-Administration and Abstinence’

Organon (PI: Linda Porrino)   
10/12/07 – 6/30/10
Schering-Plough/Organon BioSciences
Role: Co-Investigator
Metabolic Mapping of a New Test Compound 

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