Current Projects

Hayashida Lab Projects

hayashida Project 1

Figure 1: Summary of Lab project. (1) GBP reduces pre-synaptic GABA release to increase pre-synaptic glutamate release. (2) GBP enhances glutamate-induced glutamate release from astrocytes; activation of NA neurons also enhances glutamate release via gap-junctions. (3) Activation of LC by GBP results in global or selective NA release in various areas in brain and spinal cord.


 Hayashida Project 2

Figure 2: Proposed scheme by which GBP enhances glutamate release from astrocytes. (1): Glutamate acts on AMPA/mGlu receptors to increase intracellular Ca2+ levels in astrocytes. Co-transport of sodium ion and glutamate by glutamate transporters results in Ca2+ influx via the reverse mode of Na/Ca exchange. GBP enhances Ca2+ response by glutamate to augment glutamate release from astrocytes. (2): Glutamate also activates NA neurons via AMPA receptors. NA neurons serve as an amplifier of this glutamate-circuit and activation of NA neurons induces more excitation of coupled-astrocytes to enhance glutamate.

Quick Reference

Pain Mechanisms Lab

Dr. James Eisenach

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Hayashida Lab Publications

A concise list of publications by Kenichiro Hayashida, DVM, PhD, Assistant Professor, Anesthesiology specializing in pain research. 

Last Updated: 08-11-2014
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