Hayashida Lab Projects

Dr. Hayashida project mechanisms of gabapentin analgesia

Mechanisms of gabapentin analgesia in the locus coeruleus (LC).

1. Gabapentin (GBP) inhibits GABA release to increase the influence/release of glutamate. Glutamate induces Ca2+ influx through AMPA receptors to result in activation of LC neurons. GABA induces hyperpolarization of cell membrane via Cl- influx through GABA-A receptors and inhibits cell excitation. GABA also inhibits glutamate release via GABA-B receptors activation.

2. GBP induces spinal noradrenaline release as a consequence of activation of LC neurons.

Dr. Hayashida project roles of glial glutamate transporters

Roles of glial glutamate transporters on the activation of locus coeruleus neurons.

In the central nervous system, glial glutamate transporters (GLT-1 and GLAST) regulate extracellular glutamate, which stimulates various neurons via AMPA/NMDA receptors. We are now examining the functions of GLT-1 and GLAST in the locus coeruleus in normal and neuropathic pain conditions.

Last Updated 3/29/2012

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Pain Mechanisms Lab

Dr. James Eisenach
336-716-4182

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