Hayashida Lab Projects
Figure 1. Nerve injury
increases extracellular glutamate by down-regulation of GLT-1, and this
inhibits evoked glutamate release by enhanced presynaptic inhibition. The
increased glutamate concentration results in
increased tonic LC activity that impairs PFC-related cognitive function, and
the reduced evoked glutamate release diminishes noradrenergic response
important to descending inhibition of pain.