Martin Lab Projects
Under grant NS074357 from the National Institute of
Neurodegenerative Disorders and Stroke we are studying the effects of deep
brain stimulation in rats with neuropathic pain. Deep brain stimulation has
recently received renewed interest as a treatment modality for a number of CNS
disorders including chronic, intractable pain. We are interested in finding
brain regions in which electrical stimulation reverses classical symptoms of
nerve-injury associated pain in rats, such as mechanical hypersensitivity.
Additionally, using operant conditioning procedures we are interested in
finding brain regions that are uniquely reinforcing in the presence of chronic
neuropathic pain. Our goal is to find brain regions that merit investigation in
humans for relief of chronic intractable pain, as well as merit further study
for supraspinal mechanisms of analgesia in laboratory animals.