News and Events
The Pain Mechanisms Lab recently celebrated the holidays with a luncheon and door decorating contest.
The Pain Mechanisms Lab would like to introduce the following:
Katie Cunnane is currently a second-year undergraduate student at Wake Forest University. She is originally from Charlotte, North Carolina. Katie intends to major in health and exercise science and minor in neuroscience. Katie volunteers at the Children’s Center weekly through an on-campus organization called Helping to Overcome Physical Expectations (HOPE). She is a member of Tri Delta at Wake Forest. Katie also volunteers for Aceing Autism, a national organization who aims to create meaningful relationships with children with autism through tennis. Katie assists Dr. Romero-Sandoval in the pain mechanisms lab, specifically with his research in wound healing. Katie hopes to pursue a health career in pediatrics.
Miriam das Dores Mendes Fonseca is pharmacist graduated in University of Alfenas, Brazil in 2010, and received Master’s (2013) and Ph.D (2017) degree in Biological Sciences with emphasis on Pharmacology from Medical School of Ribeirao Preto, University of Sao Paulo. She has experience in the field of Pharmacology, with emphasis in pharmacology of pain and inflammation, acting mainly in the following subjects: mechanisms involved in the genesis and maintenance of chronic pain: neuropathic and inflammatory pain in different animal models, participation of the neuro-immune response, discovery and studies about actuation of analgesic drugs in these pathologies. Specifically, Fonseca has been studying for last years about the participation of the enzymes that act in the way of degradation of tryptophan and the participation of cytokines anti-inflammatory in model of neuropathic pain induced by nerve lesion. She is now a fellow research (2017) at Wake Forest University School of Medicine, Winston Salem, NC, and will work whit Dr. Romero-Sandoval in molecular mechanisms of cannabinoid receptor activation in skin and immune cells in the induction of analgesia, resolution of inflammation, and promotion of tissue repair, focused on elucidating the role of macrophages in wound healing and the transition from acute to chronic pain in the context of diabetic neuropathy or surgical pain.
The Anesthesiology Pain Mechanisms Lab would like to introduce:
Dr. Ma. Enriqueta Munoz Islas has a Biochemistry undergraduate degree (1998-2003) from the Autonomous University of Puebla, Mexico. She completed his master's degree (2004-2005) and Ph.D. (2006-2009) in Pharmacological Sciences in the Neurobiology Department at the Center for Research and Advanced Studies of the National Polytechnic Institute in Mexico City. She is currently a professor, and is responsible for the Laboratory of Vascular Pharmacology in the Reynosa Aztlán Multidisciplinary Academic Unit of the Autonomous University of Tamaulipas (UAT).
The major research focus of Dr. Munoz Islas is to investigate and understand the molecular and cellular mechanisms that regulate pain and bone loss due to Diabetes Mellitus type 1 and gestational diabetes.
During the next 5 months, Dr. Munoz-Islas will be working with Dr. Chris Peters conducting research under NIH grant number GM099863 entitled “Mechanisms involved in the transition of acute to chronic pain after surgery”. She will be assisting with anatomical and behavioral studies examining the role of endogenous and exogenous β2 adrenergic activation in the resolution of postsurgical pain using several rodent models.
Dr. Juan Miguel Jiménez Andrade has a Pharmacy undergraduate degree (1995-1999) from the Benemérita Autonomous University of Puebla, Mexico. He completed his master's degree (2000-2002) and Ph.D. (2003-2005) in Pharmacological Sciences in the External Section of Pharmacology at the Center for Research and Advanced Studies of the National Polytechnic Institute. He completed a pre-doctoral stay (2002) in the laboratory of Dr. Susan Carlton at the University of Texas, Galveston within the Department of Cell Biology and Neurosciences. He did a postdoctoral stay (2005-2007) at the University of Minnesota in the laboratory of Dr. Patrick Mantyh and also worked as an Assistant Research Professor (2007-2012) at the University of Arizona in the Department of Pharmacology. He is currently a professor, and is responsible for the Laboratory of Pharmacology in the Reynosa Aztlán Multidisciplinary Academic Unit of the Autonomous University of Tamaulipas (UAT).
The major research focus of Dr. Jimenez Andrade is to investigate and understand the molecular and cellular mechanisms that regulate musculoskeletal pain in order to develop therapies for reducing pain and improving musculoskeletal health.
During the next 5 months Dr. Jimenez-Andrade will be working with Dr. Christopher Peters conducting research under a recently funded DOD grant PC160455P1 entitled “Molecular Crosstalk: Bone Metastatic Prostate Cancer and Nociceptive Neurons”. Dr. Jimenez-Andrade will assist our lab with developing methods for conducting immunohistochemical analysis of sensory neuron innervation in skeletal tissue from mice and patients with metastatic prostate cancer.
Edgar Alfonso Romero-Sandoval, MD, PhD was recently elected by the members of the Basic Science SIG, American Pain Society (APS) co-chair of this SIG (Special Interest Group at APS). He will serve in this capacity for the next two years. More information about the APS Basic Science SIG could be found here.
Please join us in congratulating Dr. James Eisenach and Dr. Doug Ririe who were recently named to the 2017-2018 Best Doctors in America® database.
Meredith C. B. Adams, MD, MS Article Published in ASA Monitor
Dr. Meredith Adams was featured in the August issue of American Society Anesthesiologists titled "From FAER to K Grant Funding. Click here to read the entire article.
Dr. Adams works in the Anesthesiology Department at Wake Forest School of Medicine.
An Early-life Insult-induced Chronic Visceral Pain: A Possible Neuro-Molecular Mechanism
October 3, 2017
Conference Room 1064
12:00 - 1:00 pm
Presented by Jyoti N. Sengupta, MSc, PhD
Professor of Medicine
Medical College of Wisconsin
See his CV here
Assessment of Behavioral Disruption in Rats with Abdominal Inflammation Using Visual Cue Titration and the Five-choice Serial-reaction Time Task
A new study published in the journal, Anesthesiology, shows abdominal pain disrupts visual attention in rats and finds that this effect can be reversed with analgesics. To investigate the behavioral impacts of pain, a team of researchers at Wake Forest School of Medicine Anesthesiology Pain Mechanisms Lab used a recently developed variant of the classical five-choice serial-reaction time task procedure.
The research team included Thomas J. Martin, PhD, James C. Eisenach, MD, Douglas Ririe, MD, PhD, Tracy J. Strassburg, BA, Amanda L. Griff, BA, and Susy Kim, BA.
The article was accepted for publication April 26, 2017. Read full article here.
See video abstract of the paper here.
Welcome New Employees Abigail Alvarado-Vazquez, Sam Martin, and Young Gwak, PhD
Abigail Alvarado-Vazquez earned
her Bachelor's degree in Biology and Chemistry (2013) and her Master's degree
in Clinical Analysis (2015) from the Autonomous University of
Tamaulipas. In her Master's thesis, Abby studied the antinociceptive effects of
different compounds that decrease the activity of macrophages in a mouse model
of unilateral knee arthritis. During her Master's, she took a trimester as
Research Intern at Presbyterian College School of Pharmacy (PCSP) in Clinton,
SC, and later on she worked as Lab Manager for Dr. Romero-Sandoval Lab at PCSP.
Abby is now a Research Assistant in the Pain Mechanisms Laboratory under the
supervision of Dr. Romero-Sandoval. She will continue to explore the role of
macrophages in the transition from acute to chronic pain in pathologies such as
diabetic neuropathy or surgical pain.
Sam graduated in May from UNC-Greensboro with a BA in Biology and a minor in Chemistry. He breeds ball pythons and geckos and has a black belt in Tae Kwon Do.
Sam will be working in the Pain Lab as a Lab Tech II.
Dr. Gwak obtained his Ph.D. in Neuroscience at the Yonsei University,
South Korea, in 2002. His Ph.D. research focused on the elucidation of the
cellular mechanism of central neuropathic pain following spinal cord injury. As a postdoc and research scientist at the University of Texas Medical Branch (UTMB)
at Galveston (supervisor Claire E. Hulsebosch), he worked on research projects
aimed at the prevention and treatment of spinal cord induced-neuropathic pain
syndromes. Currently he is focusing his research on pain modulation via spinal
cord-mesolimbic circuits aimed at the elucidation of motivation-induced recovery
of sensory abnormality.
Congratulations to Amie Severino Alexander, PhD!
Amie Severino Alexander is now a doctor! Well, she defended her
thesis in the Fall of 2016 but came back to Winston-Salem for commencement on a
beautiful Spring day in 2017. Her work on the role of spinal oxytocin
signaling in regulating the speed of recovery from hypersensitivity after
surgery in rodents is important and will stand as an outstanding example of the
proper way to examine sex differences in pharmacology of spinal
analgesia. She is currently a post-doctoral fellow at UCLA and enjoying
the 13 mile commute by bicycle to work!
Zeidan Talks About Meditation and Pain Relief on WXII12 News
Dr. Fadel Zeidan,
assistant professor, Neurobiology and Anatomy at Wake Forest School of
Medicine, appears on WXII12 News May 8, 2017 to discuss medication and help
with pain relief.
Dr. Zeidan's research interests are in pain, meditation, brain
threshold, brain mapping and more. Click here to watch
Dr. Eisenach Receives Alumni Award 2016
James Eisenach, MD, professor of anesthesiology, has received the 2016 Mayo Clinic Distinguished Alumni Award (MCDAA).
The award acknowledges Eisenach's contributions to the understanding and treatment of pain, his leadership to the academic discipline of anesthesiology, and his training and mentoring of the next generation of physicians and scientists. Eisenach completed a residency in anesthesia at Mayo Clinic School of Graduate Medical Education in 1985 and is currently the vice chair for research in the Department of Anesthesiology at Wake Forest Baptist.
The MCDAA was established to acknowledge the contributions of Mayo Clinic alumni to the field of medicine.
Read more about Dr. Eisenach's pursuit of pain relief here.
Pain Lab Celebration Photos!