Hayashida Lab Publications

Hayashida Lab Publications 2006-2012

1. Hayashida KI, Bynum T, Vincler M, Eisenach JC. Inhibitory M2 muscarinic receptors are upregulated in both axotomized and intact small diameter dorsal root ganglion cells after peripheral nerve injury. Neuroscience 2006;140:259-68.
2. Tsuchiya T, Takeuchi T, Hayashida K, Shimizu H, Ando K, Harada E. Milk-derived lactoferrin may block tolerance to morphine analgesia. Brain Res 2006;1068:102-8.
3. Hayashida K, DeGoes S, Curry R, Eisenach JC. Gabapentin activates spinal noradrenergic activity in rats and humans and reduces hypersensitivity after surgery. Anesthesiology 2007;106:557-62.
4. Clayton BA, Hayashida K, Childers SR, Xiao R, Eisenach JC. Oral donepezil reduces hypersensitivity after nerve injury by a spinal muscarinic receptor mechanism. Anesthesiology 2007;106:1019-25.
5. Brett K, Parker R, Wittenauer S, Hayashida K, Young T, Vincler M. Impact of chronic nicotine on sciatic nerve injury in the rat. J Neuroimmunol 2007;186:37-44.
6. Hayashida K, Parker R, Eisenach JC. Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil. Anesthesiology 2007;106:1213-9.
7. Obata H, Hayashida K. [Alpha2-adrenergic receptors in the dorsal horn of the spinal cord--their function and the descending inhibitory systems]. Masui 2007;56 Suppl:S161-71.
8. Hayashida K, Clayton BA, Johnson JE, Eisenach JC. Brain derived nerve growth factor induces spinal noradrenergic fiber sprouting and enhances clonidine analgesia following nerve injury in rats. Pain 2008;136:348-55.
9. Hayashida K, Eisenach JC. Multiplicative interactions to enhance gabapentin to treat neuropathic pain. Eur J Pharmacol 2008;598:21-6.
10. Hayashida K, Obata H, Nakajima K, Eisenach JC. Gabapentin acts within the locus coeruleus to alleviate neuropathic pain. Anesthesiology 2008;109:1077-84.
11. Obata H, Hayashida KI, Nakajima K, Saito S: Alpha2-adrenoceptor as a target for the treatment of chronic pain. Pain Clinic 2008;29:239-49. [Japanese]
12. Obata H, Hayashida KI: Drug treatments for CRPS. Gabapentin and anti-depressants. Pain Clinic 2008;29:1189-97.[Japanese]
13. Obata H, Hayashida KI, Nakajima K, Saito S. Alpha2-adrenoceptor as a target for the treatment of chronic pain (Vol.2). Pain Clinic 2009;30:233-42. [Japanese]
14. Hayashida K, Parker RA, Eisenach JC. Activation of glutamate transporters in the locus coeruleus paradoxically activates descending inhibition in rats. Brain Res 2010;1317:80-6.
15. Peters CM, Hayashida K, Ewan EE, Nakajima K, Obata H, Xu Q, Yaksh TL, Eisenach JC. Lack of analgesic efficacy of spinal ondansetron on thermal and mechanical hypersensitivity following spinal nerve ligation in the rat. Brain Res 2010;1352:83-93.
16. Hayashida K, Eisenach JC. Spinal alpha 2-adrenoceptor-mediated analgesia in neuropathic pain reflects brain-derived nerve growth factor and changes in spinal cholinergic neuronal function. Anesthesiology 2010;113:406-12.
17. Hayashida K, Eisenach JC. A tropomyosine receptor kinase inhibitor blocks spinal neuroplasticity essential for the anti-hypersensitivity effects of gabapentin and clonidine in rats with peripheral nerve injury. J Pain 2011;12:94-100.
18. Hobo S, Eisenach JC, Hayashida K. Up-regulation of spinal glutamate transporters contributes to anti-hypersensitive effects of valproate in rats after peripheral nerve injury. Neurosci Lett 2011;502:52-5.
19. Hayashida KI, Peter CM. Nerve injury-induced chronic pain models. Pain Clinic 2011;32:1625-32. [Japanese]
20. Hobo S, Hayashida K, Eisenach JC. Oxytocin inhibits the membrane depolarization-induced increase in intracellular calcium in capsaicin sensitive sensory neurons: a peripheral mechanism of analgesic action. Anesth Analg. 2012;114:442-9.
21. Hayashida K, Peters CM, Gutierrez S, Eisenach JC. Depletion of endogenous noradrenaline does not prevent spinal cord plasticity following peripheral nerve injury. J Pain 2012;13:49-57.
22. Yoshizumi M, Eisenach JC, Hayashida K. Riluzole and gabapentinoids activate glutamate transporters to facilitate glutamate-induced glutamate release from cultured astrocytes. Eur J Pharmacol 2012;677:87-92.
23. Hayashida KI, Kimura M, Yoshizumi M, Hobo S, Obata H, Eisenach JC. Ondansetron reverses anti-hypersensitivity from clonidine in rats following peripheral nerve injury: Role of γ-amino butyric acid (GABA) in α2-adrenoceptor and 5-HT3 serotonin receptor analgesia. Anesthesilogy 2012: In press.
24. Yoshizumi M, Parker RA, Eisenach JC, Hayashida KI. Gabapentin inhibits γ-amino butyric acid release in the locus coeruleus but not in the spinal dorsal horn after peripheral nerve injury in rats. Anesthesiology 2012;In Press.