Proteins: Structure, Function and Genetics
A rapidly-growing research strength within the Department of Biochemistry concerns structural, functional, and genetic studies of proteins and enzymes. With an emphasis on faculty recruitment over the last 2 years, the number of faculty members with research interests in this area has recently gone from eight to twelve X-ray crystallographers. All of these Biochemistry faculty are members of the Molecular Genetics Program at Wake Forest School of Medicine. Members of this group also interact regularly with faculty from the Organic Chemistry and Biochemistry divisions of the Department of Chemistry and from the Department of Physiology/Pharmacology, and two of the bioorganic chemists also serve as faculty associates in Biochemistry.
Within the Department of Biochemistry, members of this group have been successful in initiating and establishing Core Facilities for Biomolecular Modeling and Graphics, FPLC purification of recombinant proteins, Rapid Reaction Kinetics and Spectroscopy, Time-Resolved Fluorescence, Dynamic Light Scattering, and Analytical Ultracentrifugation. The department has also recently established new facilities for high resolution structural characterization of macromolecules, including facilities for x-ray crystallography and high field NMR, and a tandem quadrapole mass spectrometer.