“… no one with an unbiased mind can study any living creature, however humble, without being struck with enthusiasm at its marvelous structure and properties.” Charles Darwin, 1874
Cells inspire the same awe. Our research is focused on understanding how cells interpret signals from their environment and translate that information into signaling pathways that then orchestrate the cellular response to a particular stimulus.
We are focused on understanding cellular signaling pathways in the human neutrophil. This type of white blood cell is an important participant in innate immunity. When activated, neutrophils generate a variety of toxic reactive oxygen species (ROS) that kill invading microorganisms and unfortunately, can damage surrounding tissues. Thus, it is important that the enzyme complex (NADPH oxidase) primarily responsible for generating these ROS be tightly regulated. It is our goal to understand the intracellular signaling pathways that turn on and turn off NADPH oxidase such that therapeutic approaches to control inappropriate activity of the enzyme could be designed. In our studies, we use primary neutrophils, cultured cell models and a variety of cell-free biochemical systems to unravel the mysteries of how information moves through cells.
Contact Info and Recent publications