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About the Center

Vision:The CIIRRC seeks to improve the burden of critical care related disorders on human health. Our approach, including prevention, treatment and recovery, will use a discovery-based model to bridge the translational research spectrum of basic, clinical, epidemiologic and health policy sciences.

Mission:Its mission is to unite distinguished, nationally-funded investigators to become a unique and cohesive venture focused on the care of the critically injured and critically ill.  The CIIRRC will integrate established research programs into multi-departmental and trans-disciplinary team science by: attracting and training new investigators in basic and clinical critical care research; connecting with local and national communities; implementing policy through evidence-based knowledge; leveraging resources across multiple Departments, Institutes and Centers, and extending value to other academic medical centers.

Center rationale:  We have assembled a matrix of 10 funded and established investigators among 5 Departments, with contributors collectively conducting research in emergency medicine, trauma and critical care that bridges the basic and clinical translational research spectrum. Our clinical trials are growing and extend nationally. Our total funding base exceeds $12 million. We perceive an opportunity to integrate and expand our research base, form teams, educate new investigators in critical care, generate new grants and ultimately improve health and health policy by forming an integrated and multidisciplinary center. Our leadership and discovery capabilities are convincing, individually recognized and already beginning to merge. Many of our research programs have integrative properties. These research and leadership attributes connect with and qualitatively enhance our Level One Trauma Center, highly active and visible Department of Emergency Medicine and our Critical Care Service Line.

Key strategic plans:  1) An innovative feature of our and others research—integration of bioenergetics and metabolism with the acute and restoration phase of the systemic inflammatory process—is informing novel therapies of sepsis  that will impact sustained muscle atrophy and  cognition compromise; 2) Our center maintains a major local and nationally connected clinical trials network; 3) our basic research  on bioenergetics and inflammation will complement investigations of cell-based therapy.

Impact and innovation: The CIIRRC is now an established named center in an area of acute illness that fills a current gap that, if our goals are completed, will positively impact our academic center and community. Innovative features includeMerging clinical trials and physiology with the evolving novel concept that the stress of acute critical injury uniformly integrates changes in  cellular bioenergetics with switches in inflammatory and metabolic clinical phenotypes (e.g.,  immunosuppression and modified glucose tolerance), which later may generate cognition compromise and muscle wasting.

Quick Reference

Critical Illness, Injury & Recovery Research Ctr
Chad Miller, MD

James Holmes, IV, MD

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Last Updated: 04-28-2016
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