About the Center
Vision:The CIIRRC seeks to
improve the burden of critical care related disorders on human health. Our
approach, including prevention, treatment and recovery, will use a
discovery-based model to bridge the translational research spectrum of basic,
clinical, epidemiologic and health policy sciences.
Mission:Its mission is to unite
distinguished, nationally-funded investigators to become a unique and cohesive
venture focused on the care of the critically injured and critically ill. The CIIRRC will integrate established
research programs into multi-departmental and trans-disciplinary team science
by: attracting and training new investigators in basic and clinical critical
care research; connecting with local and national communities; implementing
policy through evidence-based knowledge; leveraging resources across multiple
Departments, Institutes and Centers, and extending value to other academic
Center rationale: We
have assembled a matrix of 10 funded and established investigators among 5
Departments, with contributors collectively conducting research in emergency
medicine, trauma and critical care that bridges the basic and clinical
translational research spectrum. Our clinical trials are growing and extend nationally.
Our total funding base exceeds $12 million. We perceive an opportunity to
integrate and expand our research base, form teams, educate new investigators
in critical care, generate new grants and ultimately improve health and health
policy by forming an integrated and multidisciplinary center. Our leadership
and discovery capabilities are convincing, individually recognized and already
beginning to merge. Many of our research programs have integrative properties.
These research and leadership attributes connect with and qualitatively enhance
our Level One Trauma Center, highly active and visible Department of Emergency
Medicine and our Critical Care Service Line.
Key strategic plans: 1) An innovative feature of our and others
research—integration of bioenergetics and metabolism
with the acute and restoration phase of the systemic inflammatory process—is
informing novel therapies of sepsis that
will impact sustained muscle atrophy and
2) Our center maintains a major local and nationally connected clinical trials network; 3) our
basic research on bioenergetics and
inflammation will complement investigations of cell-based therapy.
Impact and innovation:
The CIIRRC is now an
established named center in an area of acute illness that fills a
current gap that, if our goals are completed, will positively impact our academic center and
community. Innovative features include: Merging
clinical trials and physiology with the evolving novel concept that the stress
of acute critical injury uniformly integrates changes in cellular bioenergetics with switches in
inflammatory and metabolic clinical phenotypes (e.g., immunosuppression and modified glucose
tolerance), which later may generate cognition compromise and muscle wasting.