Read about some of our current research projects:
Project 1: Gene-hormone interaction and risk of breast cancer
The overall hypothesis of this study is that common genetic variants can be used to classify women into low or neutral risk groups for developing breast cancer due to HT use (gene-hormone interaction). We will identify genetic variants using data and samples from the Hormone Therapy Trial (HT) of the Women's Health Initiative (WHI) study. Results from this study could benefit millions of women who suffer from menopausal symptoms. The identified genetic variants will be used to create a risk-benefit profile for HT treatment and may potentially improve clinical decision making for HT use. Individual HT-breast cancer risk assessment is important for identifying women for whom the benefits may outweigh the risks versus those women in whom the risks outweigh the benefits.
Project 2: The Role of CHD1 in DNA Rearrangements and Progression of PCa
The overall hypothesis of this study is that loss of the chromatin remodeler CHD1 leads to genomic
DNA rearrangement which results in DNA copy number alterations (CNAs) at other
critical genes, thereby driving cancer progression. The primary
goals in aim 1 are: 1) to confirm
the associations between deletion of CHD1
and CNAs identified in our pilot study, thereby to identify the CHD1 associated collaborative network in
PCa; 2) to determine whether loss of CHD1
is associated with tumorigenesis at early stages and/or cancer progression at
advanced stages. The goal of aim 2 is to evaluate the in vitro causal effects of
knockdown CHD1 expression in response to oxidative stress on DAN damage, genesis
of DNA rearrangement in terms of CNAs, differentially altered gene expression,
and cellular or growth characteristics.
In aim 3 we will explore the in vivo causal effects of loss
of CHD1 and MAP3K7 on tumorigenesis, pathological characteristics, invasion and
Project 3: The Identification of Novel, Inherited Genetic Markers for Aggressive PCa in European and African Americans Using Whole Genome Sequencing
The overall hypothesis is that inherited sequence variants in the genome are associated with a lethal (aggressive) form of PCa but not indolent PCa, and the difference in these variants between races may contribute to higher incidence of mortality from aggressive PCa in AA.