Jessica N. Cooke Bailey, BS

PhD Candidate
Molecular Medicine and Translational Science Program
Center for Genomics and Personalized Medicine Research

B.S. Biology, Honors Degree, 2008 - Winthrop University

Graduate Project

The World Health Organization (WHO) estimates that more than 180 million people worldwide have diabetes; this number is likely to more than double by 2030. Diabetes is a group of diseases marked by high levels of blood glucose, resulting from defects in insulin production and/or insulin action. Diabetes can lead to serious health complications and premature death. Type 2 diabetes (T2D) is associated with older age, obesity, family history of diabetes, impaired glucose metabolism, physical inactivity, and race/ethnicity. Complications resulting from diabetes can include: heart disease, stroke, blindness, kidney disease, nervous system disease, and amputation. One of the complications of diabetes is diabetic nephropathy – damage to the kidneys as a result of diabetes. Ten to twenty percent of diabetic patients die of kidney failure, and diabetes is the most common cause of kidney failure, accounting for nearly 44% of new cases. End-stage renal disease (ESRD) develops when nephropathy has progressed until either dialysis or a kidney transplant is necessary for life. ESRD and diabetes are complex diseases that are influenced by several factors, including environment, lifestyle, and genetics.

My research focuses on identifying genetic variants contributing to the development of diabetes and diabetic nephropathy; thus far I have conducted association studies to evaluate the influence of polymorphisms in acetyl coenzyme A carboxylase beta (ACACB) and non-muscle myosin heavy chain 9 (MYH9) on type 2 T2D-ESRD in European Americans. I am currently researching copy number variation and how it may contribute to T2D and/or T2D-ESRD in African Americans.  I am also evaluating European T2D risk variants and their cumulative contribution to T2D risk in African Americans.

Personal Background

I completed my Bachelor’s of Science degree at Winthrop University in 2008, where I majored in biology and minored in chemistry. While at Winthrop, I was a research technician, a teaching assistant for Anatomy and Microbiology laboratories, a member of the Winthrop University Honors Association, and a Winthrop Ambassador. I spent two years researching the molecular evolution of viruses including Hantavirus and Foot-and-Mouth Disease Virus using bioinformatics techniques with Dr. Kristi M. Westover.  

Selected Publications

Freedman BI, Langefeld CD, Lu L, Divers J, Comeau ME, Kopp JB, Winkler CA, Nelson GW, Johnson RC, Palmer ND, Hicks PJ, Bostrom MA, Cooke JN, McDonough CW, Bowden DW. Differential Effects of MYH9 and APOL1 Risk Variants on FRMD3 Association with Diabetic ESRD in African Americans. PLoS Genet. 2011 June; 7(6): e1002150.

McDonough CW, Palmer ND, Hicks PJ, Roh BH, An SS, Cooke JN, Hester JM, Wing MR, Bostrom MA, Rudock ME, Lewis JP, Talbert ME, Blevins RA, Lu L, Ng MC, Sale MM, Divers J, Langefeld CD, Freedman BI, Bowden DW. A genome wide association study for diabetic nephropathy genes in African Americans. Kidney Int. 2010 Dec 8. [Epub ahead of print].

Maeda S, Kobayashi MA, Araki S, Babazono T, Freedman BI, Bostrom MA, Cooke JN, Toyoda M, Umezono T, Tarnow L, Hansen T, Gaede P, Jorsal A, Ng DP, Ikeda M, Yanagimoto T, Tsunoda T, Unoki H, Kawai K, Imanishi M, Suzuki D, Shin HD, Park KS, Kashiwagi A, Iwamoto Y, Kaku K, Kawamori R, Parving HH, Bowden DW, Pedersen O, Nakamura Y. A single nucleotide polymorphism within the acetyl-coenzyme A carboxylase beta gene is associated with proteinuria in patients with type 2 diabetes. PLoS Genet. 2010 Feb 12;6(2):e1000842.

Cooke JN, Westover KM.  Serotype-specific differences in antigenic regions of foot and mouth disease virus (FMDV): A comprehensive statistical analysis.  Infect Genet Evol. 2008 Dec; 8(6): 855-63.

Selected Abstracts

Cooke JN, Bostrom MA, Hicks PJ, Ng M, Comeau ME, Divers J, Langefeld CD, Freedman BI, Bowden DW. Polymorphisms in MYH9 are Associated with Diabetic Nephropathy in European Americans. Abstract SA-PO2703. Poster displayed at the American Society of Nephrology Renal Week 2010, November 20, 2010, Denver, CO.

Cooke JN, Palmer ND, Lu L, Chou JW, McDonough CW, Freedman BI, Langefeld CD, Bowden DW. Evaluation of copy number variation in an African American type 2 diabetes and diabetic nephropathy genome-wide association study. Abstract 1806. Presented at the 60th Annual Meeting of the American Society of Human Genetics, November 3, 2010, Washington, D.C.

Cooke JN, Palmer ND, Lu L, Chou JW, Xu J, McDonough CW, Freedman BI, Langefeld CD, Bowden DW. Evaluation of copy number variation in an African American type 2 diabetes and diabetic nephropathy genome-wide association study. Presented at the 2nd annual WFU Graduate School of Arts & Sciences Biochemistry Department Student Research Day, October 8, 2010.

Cooke JN, Bostrom MA, Hicks PJ, Ng MCY, Divers J, Langefeld CD, Freedman BI, Bowden DW. Polymorphisms in MYH9 are associated with diabetic nephropathy in European Americans. Poster presented at the 10th Annual WFU Graduate School of Arts & Sciences Graduate Student and Postdoctoral Research Day, March 23, 2010.

Cooke JN, Bostrom MA, Freedman BI, Langefeld CD, Bowden DW. ACACB polymorphisms associated with type 2 diabetic nephropathy in European Americans. Presented at the 1st annual WFU Graduate School of Arts & Sciences Biochemistry Department Student Research Day, September 11, 2009.

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