Muscle Adipose eQTL Database

Adipose and Muscle Tissue Expression Quantitative Trait Loci in African Americans are associated with Obesity and Type 2 Diabetes

Link to Muscle Adipose eQTL Database

Relative to European Americans, type 2 diabetes (T2D) is more prevalent in African Americans (AAs). Genetic variation may modulate transcript abundance in insulin-responsive tissues and contribute to risk; yet published studies identifying expression quantitative trait loci (eQTLs) in African ancestry populations are restricted to blood cells. This study aims to develop a map of genetically regulated transcripts expressed in tissues important for glucose homeostasis in AAs, critical for identifying the genetic etiology of T2D and related traits. Quantitative measures of adipose and muscle gene expression (HumanHT-12 v4 Expression BeadChip; Illumina), and genotypic (HumanOmni5Exome-4 v1.1 DNA Analysis BeadChips; Illumina) data were integrated in 256 non-diabetic AAs to identify expression regulatory variants. Their roles in genetic susceptibility to T2D, and related metabolic phenotypes were evaluated by mining GWAS datasets. This study developed the first comprehensive map of adipose and muscle tissue eQTLs in AAs and identified genetically-regulated transcripts for delineating genetic causes of T2D, and related metabolic phenotypes. 

Supported by the NIH, R01 DK090111

Key Personnel involved in planning and managing database include:
Swapan K. Das, PhD
Carl D. Langefeld, PhD
Jeff W. Chou, PhD
David R. McWilliams, PhD
Neeraj K. Sharma, MS
Satria P. Sajuthi, MS
John Beal, MS



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