Janice D. Wagner, DVM PhD
Professor of Pathology (Comparative Medicine); Vice President/Senior Associate Dean for Research
Institute for Regenerative Medicine; Molecular Medicine Graduate Program; Diplomate, ACLAM, Laboratory Animal Medicine
Atherosclerosis, Estrogens, Diabetes
My major research interests involve comparative diabetes mellitus and obesity; its pathogenesis, treatments, and relationship to exacerbation of cardiovascular disease. My research group has investigated the role of obesity, insulin resistance and inflammation and their role in both progression of diabetes and exacerbation of cardiovascular disease. The adipose tissue is an important source of circulating inflammatory cytokines representing a likely link between obesity and subsequent disease risk. We have further investigated changes in pancreatic function with the progression of insulin resistance to diabetes with a particular emphasis on islet associated amyloid and its role in beta cell failure.
Another area of interest is involves the mechanisms responsible for the increased cardiovascular disease with diabetes. We are studying mechanisms whereby hyperglycemia increases oxidative stress.
I am also interested in Women’s health and nutrition, specifically in the areas of cardiovascular disease and diabetes looking at the effects of hormones and dietary soy products on lipids, insulin, and atherosclerosis.