Kylie Kavanagh, DVM MS MPH
Assistant Professor of Pathology (Comparative Medicine)
My interests lie in understanding how a chronic hyperglycaemic state changes the body's ability to cope with metabolic stress. High glucose not only increases the oxidative load on all cells but also impairs the ability to respond and cope with that insult. I am particularly interested in the chaperone proteins (heat shock protein family) and their loss of inducibility with diabetes, the changes in extracellular matrix and antioxidant super oxide dismutases which can lead to further cell damage which can manifest as endothelial dysfunction and eventual atherogenesis. We are also actively researching nutritional influences on obesity and carbohydrate metabolism, looking particularly at the effects of different fat and protein sources and hope to expand these findings into evaluating pre- and post-natal effects of maternal nutrition.