Skip Navigation

Spotlight on Susan Appt, DVM

Susan Appt, DVM, Assistant Professor of Comparative Medicine at Wake Forest School of Medicine is doing research on the effects of diet and ovarian dysfunction on risk factors for chronic diseases (i.e. heart disease, bone loss & metabolic syndrome). 

Dr. Appt uses the cynomologus macaque (M. fascicularis) model in her women’s health research because these monkeys have reproductive features that are nearly identical to women, including similar menstrual cycle lengths and hormonal patterns and natural menopause. Furthermore, they have a close phylogenetic relationship to human beings (greater than a 95% homology in DNA) and similar coronary artery anatomy/function.  

Recent data collected using this model indicate that monkeys consuming animal protein based diets may experience  more rapid ovarian aging than those that were exposed to a plant protein based diet. Another potentially important finding for women is the observation that monkeys that were reproductively older (as indicated by low antimullerian hormone-AMH) when they began consuming a high fat/high cholesterol diet typical of that consumed in the US, were at increased risk for heart disease compared to reproductively younger females. 

These data suggest a potential link between reproductive age and the susceptibility of arteries to atherosclerosis development, in the context of a non prudent diet.




Research Spotlight Index


Quick Reference

Comparative Medicine
Susan E. Appt, DVM
Section Head

Tel: 336-716-1637

E-mail Dr. Appt at

Pathology - Comparative Medicine
Wake Forest School of Medicine
Medical Center Boulevard
Winston-Salem, NC 27157
Find A Doctor Ways to Give
Last Updated: 08-15-2016
Wake Forest Baptist Ranked among Nation’s ‘Best Hospitals’  25 Years in a Row by U.S. News & World ReportComprehensive Cancer Centers National Designation is Renewed2017-2018 Best DoctorsNursing Magnet StatusJoint Commission Report

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.

© Wake Forest Baptist Medical Center, Medical Center Boulevard, Winston-Salem, NC 27157. All Rights Reserved.