Biostatistics and Bioinformatics Shared Resource

Areas of Focus

The primary goal of the Biostatistics and Bioinformatics Shared Resource (BBSR) is to facilitate the peer-reviewed research of Wake Forest Baptist Comprehensive Cancer Center (WFBCCC) members. The BBSR collaborates with members from all four scientific Programs throughout all phases of cancer-related research projects. Major responsibilities are assumed for methodological, statistical, bioinformatics, and computational issues, including study design, sampling, statistical aspects of clinical trial monitoring, interim reviews, and final analysis.

The BBSR supports the following five areas:

  1. Clinical Protocol Development, including development of appropriate statistical designs, preparing statistical sections, and reviewing the statistical content of all protocols submitted for review at the WFBCCC;
  2. Clinical Protocol Monitoring and Analyses, including monitoring patient accrual, providing support for quality assurance efforts, and performing interim (when needed) and final analyses;
  3. Statistical Design and Data Analysis in Support of Grant Development and Publications, which includes collaborations with WFBCCC investigators from all Programs to provide guidance and support in all stages of research studies and grants. This aspect of service involves meeting with WFBCCC investigators to discuss the design and analysis plans for potential grants, conducting regular planning sessions with WFBCCC investigators about potential grants, performing statistical analyses of data and providing interpretations of results as parts of presentations, abstracts, and publications;
  4. Informatics Services to WFBCCC investigators from all Programs, including genomics data processing, bioinformatics analyses, data annotation and visualization/sharing to support basic, translational and clinical cancer research by leveraging the institutionally-maintained Translational Data Warehouse; and
  5. Leadership, Education, and Training, including participation in graduate-level courses, T32 training grants, mentoring teams for K awardees and other young investigators, membership/leadership on committees responsible for scientific and administrative decisions for the WFBCCC, and coordination of a monthly seminar series and short courses on statistical and/or bioinformatics methods for WFBCCC members. 

Quick Reference

Biostatistics and Bioinformatics Shared Resource
Executive Director
Ralph D'Agostino Jr., PhD


Xiaobo Zhou, PhD

Senior Biostatisticians
Janet Tooze, PhD

Doug Case, PhD

Fang-Chi Hsu, PhD

Senior Bioinformaticians
Carl Langefeld, PhD

Guangxu Jin, PhD

Jing Su, PhD

Scott Isom, MS

Greg Russell, MS

Beverly Levine, PhD

Jeff Chou, PhD

Liang Lui, PhD

Dave McWilliams, PhD

Jian Zhang, PhD

Tina Martin, BSBA


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