Biostatistics and Bioinformatics Shared Resource
Carl D. Langefeld, Ph.D.
Director, Center for Public Health
Associate Director, Statistical
Genomics and Bioinformatics within Biostatistics
Bioinformatics Shared Resource
Professor, Department of Biostatistical
Division of Public Health Sciences
Wake Forest University School of
Winston-Salem, NC 27157
Concordia University, BA,
BS, Mathematics, Biology ( 1983)
University of Nebraska, MS, Ecology & Evolutionary
Florida State University, MS, Applied Statistics (1988)
University of Michigan, Ph.D., Biostatistics (1999)
- Statistical Genomics, Pharmacogenomics, Pharmaco-epigenetics:
- (NextGen sequence, epigenetics, gene expression, genome-wide
association analysis, genomic signatures of natural selection in human disease)
- Biostatistics and Large Data Analysis
- Statistical Machine Learning
- Analysis of clustered data (GEE1, mixed models)
- Cancer, immunology & autoimmunity, renal disease,
stroke, diabetes, obesity, metabolomics, population genetics, microevolution
Langefeld is a biostatistician whose research focuses on mapping complex
genetic traits. He has two broad areas of research: 1) identification of
genomic variation that predisposes to traits related to cancer, renal disease,
diabetes, obesity, heart disease, stroke, and autoimmunity, and 2) development
of analytic and bioinformatic methods to assist in the identification and
interpretation of this variation. He plays leadership roles in several
international genetics consortia and has served on numerous NIH (former standing
member of CASE) and foundational grant review panels. As Director of the
Center for Public Health Genomics at Wake Forest and the Associate Director of Statistical
Genomics and Bioinformatics within the Biostatistics and Bioinformatics Shared
Resource, he is very interested in developing genomics, pharmacogenomics and
precision medicine relative to cancer. In
collaboration with, David McWilliams Ph.D., Jeff Chou, Ph.D. and he has
developed DNA-seq and RNA-seq analysis pipelines, including an ION
Torrent-based DNA-seq analysis pipeline to inform childhood cancer treatment
strategies (Patrick Koty, Ph.D.). He is currently working with Drs. Glenn
Lesser and Douglas Case of the Comprehensive Cancer Center to complete a
genome-wide association study on radiation toxicity for breast cancer.
>360 peer-reviewed publications)
- Boehnke M, Langefeld CD. Genetic association mapping based on discordant sib
pairs: the discordant alleles test (DAT).
Am J Hum Genet 1998;62:950-961. PMCID: PMC1377027.
- Lange EM, Chen H, Brierley K, Livermore H, Wojno KJ, Langefeld CD, Lange K, Cooney KA. The
polymorphic exon 1 androgen receptor CAG repeat in men with a potential
inherited predisposition to prostate cancer.
Cancer Epidemiol Biomarkers Prev 2000;9:439-442. PMID: 10794490.
- Xu J, Langefeld CD, Zheng SL, GillandersEM, ChangBL, Isaacs SD, Williams
AH, Wiley KE, Dimitrov L, Meyers DA, Walsh PC, Trent JM, Isaacs WB. Interaction effect of PTEN and CDKN1B
chromosomal regions on prostate cancer linkage.
Hum Genet 2004;115; 255-262.
- Ambrosius WT, Lange EM, Langefeld CD. Power of genetic association studies with random allele
frequencies and genotype distributions.
Am J Hum Genet 2004;74:683-693. PMID: 15185141.
- Chang BL,
Lange EM, Dimitrov L, Valis CJ, Gillanders EM, Lange LA, Wiley KE, Isaacs SD,
Wiklund F, Baffoe-Bonnie A, Langefeld CD, Zheng SL, Matikainen MP,
Ikonen T, Fredriksson H, Tammela T, Walsh PA, Bailey-Wilson JE, Schleutker J,
Gronberg H, Cooney KA, Isaacs WB, Suh E, Trent JM, Xu J. Two-locus genome-wide linkage scan for
prostate cancer susceptibility genes with an interaction effect. Hum Genet 2005;23:1-9. PMID: 16328469.
- International Consortium for Systemic Lupus Erythematosus
Genetics ( SLEGEN) Harley, JB, Alarcόn-Riquelme ME, Criswell LA, Jacob CO,
Kimberly RP, Moser KL, Tsao BP, Vyse TJ,
Langefeld, CD. Genome-Wide association scan in women with
systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK,
KIAA1542 and other loci. Nat Genet
2008;Feb;40(2):204-10. PMCID: PMC3712260,
- Yu G, Herrington D, Langefeld
C, Wang Y. Detection of complex interactions of multiple SNPs. Proc. IEEE
Intl Workshop on Machine Learning for Signal Processing. Cancun, Mexico, Oct
16-19, 2008. Computational
Bioinformatics and Bio-imaging Laboratory (CBIL) Conference Paper pp. 85-90.
- Jacob CO, Zhu J, Armstrong DL, Yan M, Han J, Ahou XJ, Reiff
A, Myones BL, Ojwang JO, Kaufman KM, Klein-Gitelman M, McCurdy D, Wagney-Weiner
L, Silverman E, Ziegler J, Kelly JA, Merrill JT, Harley JB, James JA,
Ramsey-Goldman R, Vila LM, Bae SC, Vyse TJ, Gilkeson GS, Gaffney PM, Moser KL, Langefeld CD, Zidovetzki R, Mohan C.
Identification of IRAK1 as a risk gene with critical role in the pathogenesis
of systemic lupus erythematosus. ProcNatlAcadSci USA. 2009 Apr
14;106(15):6256-61. PMCID: PMC2669395.
- Gu Y, Harley IT, Henderson LB, Aronow BJ, Vietor I, Huber LA, Harley JB,
Kilpatrick JR, Langefeld CD,
Williams AH, Jegga AG, Chen J, Wills-Karp M, Arshad SH, Ewart SL, Thio CL,
Flick LM, Filippi MD, Grimes HL, Drumm ML, Cutting GR, Knowles MR, Karp CL.
Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease.
Nature. 2009 Apr 23;458(7241):1039-42. PMCID:
- Harley IT, Kaufman KM, Langefeld CD, Harley JB, Kelly JA. Genetic
susceptibility to SLE: new insights from
fine mapping and genome-wide association studies. Nat Rev Genet. 2009
May;10(5):285-90. PMCID: PMC2737697.
- Miller DJ, Zhang Y, Yu G, Liu Y, Chen L, Langefeld CD, Herrington D, Wang
Y. An Algorithm for learning maximum
entropy probability models of disease risk that efficiently searches and
sparingly encodes multilocus genomic interactions. Bioinformatics. 2009 Oct
1;25(19):2478-85. PMCID: PMC3140808.
- International Stroke Genetics Consortium; Wellcome Trust
Case-Control Consortium 2. Failure to validate
association between 12p13 variants and ischemic stroke.N
Engl J Med. 2010 Apr 22;362(16):1547-50. No abstract
- Genovese G, Friedman DJ, Ross MD, Lecordier L, Uzureau P,
Freedman BI, Bowden DW, Langefeld CD,
Oleksyk TK, Uscinski Knob AL, Bernhardy AJ, Hicks PJ, Nelson GW, Vanhollebeke
B, Winkler CA, Kopp JB, Pays E, Pollak MR. Association of
trypanolytic ApoL1 variants with kidney disease in African Americans.
RT, Santago P, Langefeld CD.
Bootstrap aggregating of alternating decision trees to detect sets of SNPs that
associated with disease. Genet Epidemiol 2012 Feb;36(2):99-106. PMCID:
- Bowden DW, An SS, Palmer ND, Brown WM, Norris JM, Haffner
SM, Hawkins GA, Guo X, Rotter JI, Chen YD, Wagenknecht LE, Langefeld CD. Molecular basis of a
linkage peak: exome sequencing and family-based analysis identify a rare genetic
variant in the ADIPOQ gene in the IRAS Family Study. Hum Mol Genet. 2010; 19:4112-20. PMCID: PMC2947405.