Biostatistics and Bioinformatics Shared Resource
David R. McWilliams, Ph.D.
Center for Public Health Genomics
of Biostatistical Sciences
Division of Public Health Sciences
Wake Forest School of Medicine
Winston-Salem, NC 27157
University of Tennesse, Knoxville – Ph.D.
Duke University, Durham, NC – MS, Natural
Products Organic Chemistry
Davidson College, Davidson, NC – BS,
Chemistry and Biology
- Bioinformatic tool development
Dr. McWilliams has extensive
experience with both laboratory science and informatics, in both industrial and
academic settings. He has bioinformatic
experience with lipid, polysaccharide, proteomic and genetic data. As a consulting scientist he created
web-based interfaces to databases and R analysis packages to facilitate use by
biologists. Since his employment in the
Department of Biostatistical Sciences he has created automated bioinformatic
pipelines for next-generation sequencing data using open-source tools such as
Samtools, Picard, GATK, perl and R.
JN, Lu L, Chou JW, Xu J, McWilliams DR,
Howard TD, Freedman BI, Bowden DW, Langefeld CD, Palmer ND. The Role of Copy
Number Variation in African Americans with Type 2 Diabetes-Associated End Stage
Renal Disease. J. Mol. Genet. Med. 2013; 7:61. PMCID: PMC3973178.
- Chotewutmontri P, Reddick LE, McWilliams DR, Campbell IM, Bruce BD. Differential transit peptide recognition
during preprotein binding and translocation into flowering plant plastids.
Plant Cell. 2012;24(7):3040-59. PMCID: PMC3426131.
- Liberles DA, Shinozaki K, Bruce BD, Boutry M,
Glaser E, Bhushan S, Stahl A, Nilsson S, Lefebvre B, Seki M, Roth C, McWilliams D, Wright SJ. Catalysis, subcellular localization,
expression and evolution of the targeting peptides degrading protease,
AtPreP2. Plant Cell Physiol. 2005 Jun;46(6):985-96K. PMID: 15827031.
- Ehrhardt C, Hopkins JB, Maheras JC, and McWilliams, DR. Method for Immobilizing Superabsorbent
Polymer and Products Derived Therefrom.
- Jeffs, PW, and McWilliams,
D. Carbon-13 Nuclear Magnetic Resonance Study of the Biosynthesis of
Cycloheximide. Stereospecific Incorporation
of Malonate into the Glutarimide Ring. J. Am. Chem. Soc. 1981, 103:6185.