Biostatistics and Bioinformatics Shared Resource
Doug Case, Ph.D.
Department of Biostatistical Sciences
Forest University School of Medicine
Medical Center Blvd.
Winston-Salem, NC 27157
Tel: (336) 716-1048
UNC-Chapel Hill - BS Math, MSPH Biostatistics, PhD
- Group Sequential Designs
Methods in Cancer Research
Case is a Professor in the Department of Biostatistical Sciences, Division of
Public Health Sciences, at Wake Forest University. He was formerly the Director
of the Cancer Center Biostatistics Core, the head of the Biostatistics Core of
the DOD Behavioral Center of Excellence in Breast Cancer, and the PI of the
Statistical Center for the Ischemia Stroke Genetics Study, a five-center
case-control study looking at the association between genetic markers and the
risk of stroke. Currently he is the PI of the Data Coordinating Center for
REST-IT, a multi-center randomized clinical trial in patients with depression,
and the senior statistician for the Wake Forest Research Base, which provides
the infrastructure for conducting cancer prevention, symptom management, and
cancer care delivery clinical trials in the NCI Community Oncology Research
Program. His research interests include group sequential designs, study designs
with time to event endpoints, and statistical graphics.
- Case LD,
Morgan TM. Duration of accrual and
follow-up for two-stage clinical trials.
Lifetime Data Anal 2001;7(1):21-37. PMID: 11280845.
- Case LD, Morgan TM. Design of phase II
trials evaluating survival probabilities. BMC Med Res 2003;3:6. PMCID:PMC161809
- Vitolins MZ,
Kimmick GG, Case LD. BMI affects prognosis following surgery and
adjuvant chemotherapy for stage II breast cancer. The Breast Journal 2008:14;357-365.
W, Case LD, Blackwell K, Marcom PK,
Kraus, W, Aziz N, Snyder DC, Giguere JK, Shaw E. Results of a diet/exercise feasibility trial
to prevent adverse body composition change in breast cancer patients on
adjuvant chemotherapy. Clinical Breast
Cancer 2008 Feb;8(1):70-79. PMID: 18501061.
- Sukumvanich P, Case LD, Van Zee K, Singletary SE,
Paskett ED, Petrek JA, Naftalis E, Naughton MJ.
Incidence and time
course of bleeding after long-term amenorrhea after breast cancer treatment: a
prospective study. Cancer. 2010 Jul 1;116(13):3102-3111.
- Miller DP, Spangler
JG, Case LD, Goff DC, Singh S,
Pignone MP. Effectiveness of a
web-based colorectal cancer screening patient decision aid: a randomized
controlled trial in a mixed-literacy population.
Am J Prev Med 2011 Jun;40:608-615.
- High KP, Case D, Hurd D, Powell B, Lesser G,
Falsey AR, Siegel R, Metzner-Sadurski J, Krauss JC, Chinnasami B, Sanders G,
Rousey S, Shaw EG. A Randomized,
Controlled Trial of Panax quinquefolius Extract (CVT-E002) to Reduce
Respiratory Infection in Patients With Chronic Lymphocytic Leukemia. J Support Oncol, 2012
Sept-Oct;10(5):196-201. PMCID: PMC3337952
- Danhauer SC, Case D, Tedeschi R, Russell G,
Vishnevsky T, Triplett K, Ip E, Avis NE.
Predictors of Posttraumatic Growth in Women with Breast Cancer. PsychoOncology. December 2013, 22(12), 2676-2683.
- Foy CG, Vitolins MZ, Case LD, Harris
SJ, Massa-Fanale C, Hopley RJ, Gardner LE, Rudiger N, Yamamoto K, Swain B, Goff
DC, Danhauer SC, Booth D, Gaspari J. Incorporating prosocial behavior to
promote physical activity in older adults: rationale and design of the Program
for Active Aging and Community Engagement (PACE). Contemporary Clinical Trials. September 2013,
- Lesser GL, Case D, Stark N, Williford
S, Giguere J, Garino LA, Naughton MJ, Vitolins MZ, Lively MO, Shaw EG. A Randomized,
Double-Blind, Placebo-Controlled Study of Oral Coenzyme Q10 to Relieve
Self-Reported Treatment-Related Fatigue in Newly Diagnosed Patients with Breast
Cancer. J Supportive
Oncology. March 2013, 11, 31-42.
- Morgan TM, Case LD. Conservative sample
size determination for repeated measures analysis of covariance. Annals of Biom Biostat. 2013, 1:1002. PMID: 25045756.
- Weaver KE, Palmer N, Lu L, Case
LD, Geiger AM. Rural-Urban Differences in Health Behaviors and Implications
for Health Status among US Cancer Survivors.
Cancer Causes and Control. 2013, 24, 1481–1490.
- Vitolins MZ, Milliron B-J, Hopkins JO, Fulmer
A, Lawrence J, Melin S, Case D. Weight loss intervention in survivors of
ER/PR negative breast cancer. Clinical
Medicine Insight: Women’s Health June 2014, 7:17-24. PMCID: PMC4069035.
- Greven KM, Case LD, Nycum LR,
Zekan PJ, Hurd DD, Balcueva EP, Mills GM,
Zon R, Flynn PJ, Biggs D, Shaw EG,
Naughton MJ. A Randomized Study to Determine Whether ArginMax Improves the
Sexual Function and Quality of Life of Female Cancer Survivors. JCSO. 2015, In Press.
- Rapp S, Case D, Peiffer A, Naughton M,
Chan M, Stieber V, Bayer G, Bilodeau P,
Moore D, Falchuk S, Needles B, Piephoff J,
Wedenfield W, Giguere J, Nicolette E, Loghin M
and Shaw E. Donepezil
Following Cranial Irradiation for Brain Tumors:
A Phase III Randomized, Placebo-Controlled Clinical Trial. JCO. 2015, In Press.