Biostatistics and Bioinformatics Shared Resource

Doug Case, Ph.D.

Case_Doug_Cropped

Professor
Department of Biostatistical Sciences 
Wake Forest University School of Medicine
Medical Center Blvd.
Winston-Salem, NC 27157
Tel: (336) 716-1048
Fax: (336)716-6427
Email: dcase@wakehealth.edu

Education

UNC-Chapel Hill - BS Math, MSPH Biostatistics, PhD Biostatistics

Research Topics

  • Group Sequential Designs
  • Statistical Graphics
  • Statistical Methods in Cancer Research

Current Research

Dr. Case is a Professor in the Department of Biostatistical Sciences, Division of Public Health Sciences, at Wake Forest University. He was formerly the Director of the Cancer Center Biostatistics Core, the head of the Biostatistics Core of the DOD Behavioral Center of Excellence in Breast Cancer, and the PI of the Statistical Center for the Ischemia Stroke Genetics Study, a five-center case-control study looking at the association between genetic markers and the risk of stroke. Currently he is the PI of the Data Coordinating Center for REST-IT, a multi-center randomized clinical trial in patients with depression, and the senior statistician for the Wake Forest Research Base, which provides the infrastructure for conducting cancer prevention, symptom management, and cancer care delivery clinical trials in the NCI Community Oncology Research Program. His research interests include group sequential designs, study designs with time to event endpoints, and statistical graphics. 

Selected Publications

  1. Case LD, Morgan TM.  Duration of accrual and follow-up for two-stage clinical trials.  Lifetime Data Anal 2001;7(1):21-37. PMID: 11280845.
  2. Case LD, Morgan TM.  Design of phase II trials evaluating survival probabilities.  BMC Med Res 2003;3:6.  PMCID:PMC161809
  3. Vitolins MZ, Kimmick GG, Case LD.   BMI affects prognosis following surgery and adjuvant chemotherapy for stage II breast cancer.  The Breast Journal 2008:14;357-365.
  4. Demark-Wahnefried W, Case LD, Blackwell K, Marcom PK, Kraus, W, Aziz N, Snyder DC, Giguere JK, Shaw E.  Results of a diet/exercise feasibility trial to prevent adverse body composition change in breast cancer patients on adjuvant chemotherapy.  Clinical Breast Cancer 2008 Feb;8(1):70-79. PMID: 18501061.
  5. Sukumvanich P, Case LD, Van Zee K, Singletary SE, Paskett ED, Petrek JA, Naftalis E, Naughton MJ.  Incidence and time course of bleeding after long-term amenorrhea after breast cancer treatment: a prospective study.  Cancer. 2010 Jul 1;116(13):3102-3111.
  6. Miller DP, Spangler JG, Case LD, Goff DC, Singh S, Pignone MP. Effectiveness of a web-based colorectal cancer screening patient decision aid: a randomized controlled trial in a mixed-literacy population. Am J Prev Med 2011 Jun;40:608-615.  PMCID:PMC3480321
  7. High KP, Case D, Hurd D, Powell B, Lesser G, Falsey AR, Siegel R, Metzner-Sadurski J, Krauss JC, Chinnasami B, Sanders G, Rousey S, Shaw EG.  A Randomized, Controlled Trial of Panax quinquefolius Extract (CVT-E002) to Reduce Respiratory Infection in Patients With Chronic Lymphocytic Leukemia.  J Support Oncol, 2012 Sept-Oct;10(5):196-201.  PMCID:  PMC3337952
  8. Danhauer SC, Case D, Tedeschi R, Russell G, Vishnevsky T, Triplett K, Ip E, Avis NE.  Predictors of Posttraumatic Growth in Women with Breast Cancer.  PsychoOncology. December 2013, 22(12), 2676-2683. 
  9. Foy CG, Vitolins MZ, Case LD, Harris SJ, Massa-Fanale C, Hopley RJ, Gardner LE, Rudiger N, Yamamoto K, Swain B, Goff DC, Danhauer SC, Booth D, Gaspari J. Incorporating prosocial behavior to promote physical activity in older adults: rationale and design of the Program for Active Aging and Community Engagement (PACE).  Contemporary Clinical Trials. September 2013, 36(1), 284-297.
  10. Lesser GL, Case D, Stark N, Williford S, Giguere J, Garino LA, Naughton MJ, Vitolins MZ, Lively MO, Shaw EG.  A Randomized, Double-Blind, Placebo-Controlled Study of Oral Coenzyme Q10 to Relieve Self-Reported Treatment-Related Fatigue in Newly Diagnosed Patients with Breast Cancer.  J Supportive Oncology.  March 2013, 11, 31-42.
  11. Morgan TM, Case LD. Conservative sample size determination for repeated measures analysis of covariance.  Annals of Biom Biostat.  2013, 1:1002. PMID: 25045756.
  12. Weaver KE, Palmer N, Lu L, Case LD, Geiger AM. Rural-Urban Differences in Health Behaviors and Implications for Health Status among US Cancer Survivors.  Cancer Causes and Control. 2013, 24, 1481–1490.
  13. Vitolins MZ, Milliron B-J, Hopkins JO, Fulmer A, Lawrence J, Melin S, Case D. Weight loss intervention in survivors of ER/PR negative breast cancer.  Clinical Medicine Insight: Women’s Health June 2014, 7:17-24. PMCID: PMC4069035.
  14. Greven KM, Case LD, Nycum LR, Zekan PJ, Hurd DD, Balcueva EP, Mills GM, Zon R, Flynn PJ, Biggs D, Shaw EG, Naughton MJ. A Randomized Study to Determine Whether ArginMax Improves the Sexual Function and Quality of Life of Female Cancer Survivors.  JCSO. 2015, In Press.
  15. Rapp S, Case D, Peiffer A, Naughton M, Chan M, Stieber V, Bayer G, Bilodeau P, Moore D, Falchuk S, Needles B, Piephoff J, Wedenfield W, Giguere J, Nicolette E, Loghin M and Shaw E.  Donepezil Following Cranial Irradiation for Brain Tumors:  A Phase III Randomized, Placebo-Controlled Clinical Trial.  JCO. 2015, In Press.

Quick Reference

Biostatistics and Bioinformatics Shared Resource
Executive Director
Ralph D'Agostino Jr., PhD

336-716-9410
336-716-9011

rdagosti@wakehealth.edu

Co-Director
Xiaobo Zhou, PhD

xizhou@wakehealth.edu

Senior Biostatisticians
Janet Tooze, PhD

jtooze@wakehealth.edu

Doug Case, PhD

dcase@wakehealth.edu

Fang-Chi Hsu, PhD

fhsu@wakehealth.edu

Senior Bioinformaticians
Carl Langefeld, PhD

clangefe@wakehealth.edu

Guangxu Jin, PhD

gjin@wakehealth.edu

Jing Su, PhD

jsu@wakehealth.edu

Biostatisticians
Scott Isom, MS

sisom@wakehealth.edu

Greg Russell, MS

grussell@wakehealth.edu

Beverly Levine, PhD

blevine@wakehealth.edu

Bioinformaticians
Jeff Chou, PhD

jchou@wakehealth.edu

Liang Lui, PhD

lliu@wakehealth.edu

Dave McWilliams, PhD

dmcwilli@wakehealth.edu

Jian Zhang, PhD

jizhang@wakehealth.edu

Administrator
Tina Martin, BSBA

timartin@wakehealth.edu

 

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