Biostatistics and Bioinformatics Shared Resource
Fang-Chi Hsu, Ph.D.
Department of Biostatistical Sciences
of Public Health Sciences
Forest School of Medicine
Medical Center Blvd.
Winston-Salem, NC 27157
Tel: (336) 716-8457
National Taiwan University – BPH, Public Health
National Taiwan University – MS, Biostatistic
Johns Hopkins University – PhD, Biostatistics
- Statistical genetics
- Longitudinal data
Dr. Hsu is an
Associate Professor in the Department of Biostatistical Sciences, Division of
Public Health Sciences, at Wake Forest School of Medicine. Her methodological research is focused on the design and analysis of
genetic studies. Specifically, she is
interested in genetic risk prediction, gene-gene interactions, genetic
association studies, and high dimensional data analysis. For the past several years, she and her
colleagues have developed a robust multipoint linkage disequilibrium method for
estimating the chromosomal location of an unobserved trait locus when a
case-parent trio study design is adopted, and extended it to handle
quantitative traits in offspring and also to examine gene-gene and
gene-environment interactions. The
software is available for public use.
Recently, she is interested in risk prediction in genetic studies. She and her colleagues have published several
papers in the top tier journals in this area.
They also have applied support vector machine and combinatorial
optimization techniques to detect gene-gene interactions in prostate cancer
studies. In addition, she participates in
several clinical trials and observational studies in the areas of cancer, aging,
diabetes, cardiovascular diseases, obesity, and farm workers. She provides expertise in the study design,
data management and monitoring, and analytic support.
- Hsu FC, Liang KY, Beaty TH, Barnes KC. Unified sampling approach for multipoint
linkage disequilibrium mapping of qualitative and quantitative traits. Genet Epidemiol 2002;22(4):298-312. PMID: 11984863.
- Hsu FC, Liang KY, Beaty TH. Multipoint linkage disequilibrium mapping
approach incorporating evidence of linkage and linkage disequilibrium from
unlinked region. Genet Epidemiol
2003;25(1):1-13. PMID: 12813722.
- Zhao W, Payne V,
Tomassi E, Diz DI, Hsu FC, Robbins
ME. Administration of the peroxisomal proliferator-activated receptor gamma
agonist pioglitazone during fractionated brain irradiation prevents
radiation-induced cognitive impairment.Int
J Radiat Oncol Biol Phys 2007;67:6-9. PMID: 17189061.
- Zheng SL, Sun J,
Cheng Y, Li G, Hsu FC, Zhu Y, Chang
BL, Liu W, Kim JW, Turner AR, Gielzak M, Yan G, Isaacs SD, Wiley KE, Sauvageot
J, Chen HS, Gurganus R, Mangold LA, Trock BJ, Gronberg H, Duggan D, Carpten JD,
Partin AW, Walsh PC, Xu J, Isaacs WB. Association between two unlinked loci at
8q24 and prostate cancer risk among European Americans. J Natl Cancer Inst 2007;99:1525-1533. PMID: 17925536.
- Chen SH, Sun J,
Dimitrov L, Turner AR, Adams TS, Meyers DA, Chang BL, Zheng SL, Grönberg H,
Xu J, Hsu FC.A support vector
machine approach for detecting gene-gene interaction. Genet Epidemiol 2008;32:152-167. PMID: 17968988.
- Zheng SL, Sun J,
Wiklund F, Smith S, Stattin P, Li G, Adami HO, Hsu FC, Zhu Y, Balter K, Kader AK, Turner AR, Liu W, Bleecker ER,
Meyers DA, Duggan D, Carpten JD, Chang BL, Isaacs WB, Xu J, Gronberg H.
Cumulative association of five genetic variants with prostate cancer. N Engl J Med 2008;358:910-919. PMID: 18199855.
- Hsu FC, Lindström S, Sun J, Wiklund F, Chen SH,
Adami HO, Turner AR, Liu W, Bälter K, Kim JW, Stattin P, Chang BL, Isaacs WB,
Xu J, Grönberg H, Zheng SL. A multigenic approach to evaluating prostate cancer
risk in a systematic replication study. Cancer
Genet Cytogenet 2008;183:94-98. PMCID: PMC2945815.
- Sun J, Zheng SL,
Wiklund F, Isaacs SD, Purcell LD, Gao Z, Hsu
FC, Kim ST, Liu W, Zhu Y, Stattin P, Adami HO, Wiley KE, Dimitrov L, Sun J,
Li T, Turner AR, Adams TS, Adolfsson J, Johansson JE, Lowey J, Trock BJ, Partin
AW, Walsh PC, Trent JM, Duggan D, Carpten J, Chang BL, Gronberg H, Isaacs WB,
Xu J. Evidence for two independent prostate cancer risk-associated loci in the
HNF1B gene at 17q12. Nat Genet 2008;40:1153-1155. PMCID: PMC3188432.
- Robbins ME, Payne
V, Tommasi E, Diz DI, Hsu FC, Brown
WR, Wheeler KT, Olson J, Zhao W. The AT1 receptor antagonist,
L-158,809, prevents or ameliorates fractionated whole-brain irradiation-induced
cognitive impairment. Int J Radiat Oncol
Biol Phys 2009;73:499-505. PMCID: PMC2631653.
- Hsu FC, Sun J, Wiklund F, Isaacs SD, Wiley
K, Purcell LD, Gao Z, Stattin P, Zhu Y, Kim ST, Zhang Z, Liu W, Chang BL, Walsh
PC, Duggan D, Carpten JD, Isaacs WB, Grönberg H, Xu J, Zheng SL. A novel
prostate cancer susceptibility locus at 19q13. Cancer Res. 2009;69:2720-2723. PMCID: PMC2803342.
- Hsu FC, Sun J, Zhu Y, Kim ST, Jin T, Zhang Z,
Wiklunds F, Kader AK, Zheng SL, Isaacs W, Grönberg H,
Xu J. Comparison of two methods for estimating absolute risk of prostate cancer
based on single nucleotide polymorphisms and family history. Cancer Epidemiol Biomarkers Prev 2010;19:1083-1088. PMCID: PMC2852494.
- Chen SH, Ip EH, Xu
J, Sun J, Hsu FC. Using graded
response model for the prediction of prostate cancer risk. Hum Genet. 2012;131:1327-1336. PMCID: PMC3734950.
- Sun J*, Na R*, Hsu FC*, Zheng SL, Wiklund F, Condreay
LD, Trent JM, Xu J. Genetic score is an objective and better measurement of
inherited risk of prostate cancer than family history. Eur Urol 2013;63(3):585-587. PMCID: PMC3730447 (*:
J, Skrivankova V, Hsu FC, Sale M,
Heagerty P. Detecting signals in pharmacogenomics genome-wide association studies.
The Pharmacogenomics Journal
2014;14(4):309-315. PMCID: PMC4085158.
JY, Lu W, Hsu FC. Gene-level
pharmacogenetic analysis on survival outcomes by gene-trait similarity
regression. Ann Appl Stat
2014;8(2):1232-1255. PMCID: PMC4091797.