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Biostatistics and Bioinformatics Shared Resource

Fang-Chi Hsu, Ph.D.


Associate Professor
Department of Biostatistical Sciences
Division of Public Health Sciences
Wake Forest School of Medicine
Medical Center Blvd.
Winston-Salem, NC 27157
Tel: (336) 716-8457
Fax: (336)716-6427


National Taiwan University – BPH, Public Health
National Taiwan University – MS, Biostatistic
Johns Hopkins University – PhD, Biostatistics    

Research Topics

  • Statistical genetics
  • Epigenetics
  • Pharmacogenomics
  • Longitudinal data analysis
  • Clinical trials    

Current Research

Dr. Hsu is an Associate Professor in the Department of Biostatistical Sciences, Division of Public Health Sciences, at Wake Forest School of Medicine. Her methodological research is focused on the design and analysis of genetic studies.  Specifically, she is interested in genetic risk prediction, gene-gene interactions, genetic association studies, and high dimensional data analysis.  For the past several years, she and her colleagues have developed a robust multipoint linkage disequilibrium method for estimating the chromosomal location of an unobserved trait locus when a case-parent trio study design is adopted, and extended it to handle quantitative traits in offspring and also to examine gene-gene and gene-environment interactions.  The software is available for public use.  Recently, she is interested in risk prediction in genetic studies.  She and her colleagues have published several papers in the top tier journals in this area.  They also have applied support vector machine and combinatorial optimization techniques to detect gene-gene interactions in prostate cancer studies.  In addition, she participates in several clinical trials and observational studies in the areas of cancer, aging, diabetes, cardiovascular diseases, obesity, and farm workers.  She provides expertise in the study design, data management and monitoring, and analytic support.

Selected Publications

  1. Hsu FC, Liang KY, Beaty TH, Barnes KC.  Unified sampling approach for multipoint linkage disequilibrium mapping of qualitative and quantitative traits. Genet Epidemiol 2002;22(4):298-312. PMID: 11984863.
  2. Hsu FC, Liang KY, Beaty TH.  Multipoint linkage disequilibrium mapping approach incorporating evidence of linkage and linkage disequilibrium from unlinked region. Genet Epidemiol 2003;25(1):1-13. PMID: 12813722.
  3. Zhao W, Payne V, Tomassi E, Diz DI, Hsu FC, Robbins ME. Administration of the peroxisomal proliferator-activated receptor gamma agonist pioglitazone during fractionated brain irradiation prevents radiation-induced cognitive impairment.Int J Radiat Oncol Biol Phys 2007;67:6-9. PMID: 17189061.
  4. Zheng SL, Sun J, Cheng Y, Li G, Hsu FC, Zhu Y, Chang BL, Liu W, Kim JW, Turner AR, Gielzak M, Yan G, Isaacs SD, Wiley KE, Sauvageot J, Chen HS, Gurganus R, Mangold LA, Trock BJ, Gronberg H, Duggan D, Carpten JD, Partin AW, Walsh PC, Xu J, Isaacs WB. Association between two unlinked loci at 8q24 and prostate cancer risk among European Americans. J Natl Cancer Inst 2007;99:1525-1533. PMID: 17925536.
  5. Chen SH, Sun J, Dimitrov L, Turner AR, Adams TS, Meyers DA, Chang BL, Zheng SL, Grönberg H, Xu J, Hsu FC.A support vector machine approach for detecting gene-gene interaction. Genet Epidemiol 2008;32:152-167. PMID: 17968988.
  6. Zheng SL, Sun J, Wiklund F, Smith S, Stattin P, Li G, Adami HO, Hsu FC, Zhu Y, Balter K, Kader AK, Turner AR, Liu W, Bleecker ER, Meyers DA, Duggan D, Carpten JD, Chang BL, Isaacs WB, Xu J, Gronberg H. Cumulative association of five genetic variants with prostate cancer. N Engl J Med 2008;358:910-919. PMID: 18199855.
  7. Hsu FC, Lindström S, Sun J, Wiklund F, Chen SH, Adami HO, Turner AR, Liu W, Bälter K, Kim JW, Stattin P, Chang BL, Isaacs WB, Xu J, Grönberg H, Zheng SL. A multigenic approach to evaluating prostate cancer risk in a systematic replication studyCancer Genet Cytogenet 2008;183:94-98. PMCID: PMC2945815.
  8. Sun J, Zheng SL, Wiklund F, Isaacs SD, Purcell LD, Gao Z, Hsu FC, Kim ST, Liu W, Zhu Y, Stattin P, Adami HO, Wiley KE, Dimitrov L, Sun J, Li T, Turner AR, Adams TS, Adolfsson J, Johansson JE, Lowey J, Trock BJ, Partin AW, Walsh PC, Trent JM, Duggan D, Carpten J, Chang BL, Gronberg H, Isaacs WB, Xu J. Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12. Nat Genet 2008;40:1153-1155. PMCID: PMC3188432.
  9. Robbins ME, Payne V, Tommasi E, Diz DI, Hsu FC, Brown WR, Wheeler KT, Olson J, Zhao W. The AT1 receptor antagonist, L-158,809, prevents or ameliorates fractionated whole-brain irradiation-induced cognitive impairment. Int J Radiat Oncol Biol Phys 2009;73:499-505. PMCID: PMC2631653.
  10. Hsu FC, Sun J, Wiklund F, Isaacs SD, Wiley K, Purcell LD, Gao Z, Stattin P, Zhu Y, Kim ST, Zhang Z, Liu W, Chang BL, Walsh PC, Duggan D, Carpten JD, Isaacs WB, Grönberg H, Xu J, Zheng SL. A novel prostate cancer susceptibility locus at 19q13. Cancer Res. 2009;69:2720-2723. PMCID: PMC2803342.
  11. Hsu FC, Sun J, Zhu Y, Kim ST, Jin T, Zhang Z, Wiklunds F, Kader AK, Zheng SL, Isaacs W, Grönberg H, Xu J. Comparison of two methods for estimating absolute risk of prostate cancer based on single nucleotide polymorphisms and family history. Cancer Epidemiol Biomarkers Prev 2010;19:1083-1088. PMCID: PMC2852494.
  12. Chen SH, Ip EH, Xu J, Sun J, Hsu FC. Using graded response model for the prediction of prostate cancer risk. Hum Genet. 2012;131:1327-1336. PMCID: PMC3734950.
  13. Sun J*, Na R*, Hsu FC*, Zheng SL, Wiklund F, Condreay LD, Trent JM, Xu J. Genetic score is an objective and better measurement of inherited risk of prostate cancer than family history. Eur Urol 2013;63(3):585-587. PMCID: PMC3730447 (*: co-first authors).
  14. Wakefield J, Skrivankova V, Hsu FC, Sale M, Heagerty P. Detecting signals in pharmacogenomics genome-wide association studies. The Pharmacogenomics Journal 2014;14(4):309-315. PMCID: PMC4085158.
  15. Tzeng JY, Lu W, Hsu FC. Gene-level pharmacogenetic analysis on survival outcomes by gene-trait similarity regression. Ann Appl Stat 2014;8(2):1232-1255. PMCID: PMC4091797.

Quick Reference

Biostatistics and Bioinformatics Shared Resource
Executive Director
Ralph D'Agostino Jr., PhD


Xiaobo Zhou, PhD

Senior Biostatisticians
Janet Tooze, PhD

Doug Case, PhD

Fang-Chi Hsu, PhD

Senior Bioinformaticians
Carl Langefeld, PhD

Guangxu Jin, PhD

Jing Su, PhD

Scott Isom, MS

Greg Russell, MS

Beverly Levine, PhD

Jeff Chou, PhD

Liang Lui, PhD

Dave McWilliams, PhD

Jian Zhang, PhD

Tina Martin, BSBA


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