Scientific Focus and Rationale: Cellular Damage and Defense Program
There are three research themes within the Cellular Damage and Defense Program:
DNA Damage and Genomic Integrity
The DNA damage and Genomic Integrity group has a common goal of understanding the metabolism of DNA and how the processes maintain genomic integrity.
Members is this thematic group work on mismatch repair (MMR) in cancer, the role of fragile site in genomic maintenance, DNA processing by exonucleases, the role of unusual DNA structures, and the development of novel genotoxic agents. Collaborations between biologists, X-ray crystallographers, physicists and chemists provide synergistic enhancement to the scientific capabilities of this group.
The Redox Signaling group has a common goal of understanding redox regulation and the role of reactive oxygen species (ROS) in cancer and its response to various therapeutic interventions.
Members in this thematic group work on ROS-mediated signaling, redox proteomic profiling, radiation-induced brain injury and structural biology. Collaborations between biologists, biochemists, chemists, X-ray crystallographers and physicists bring synergy to this group by providing expertise that would otherwise be unavailable.
The Cellular Metabolism group is focused on understanding how diverse metabolic pathways contribute to the control of tumor growth.
Members of this thematic group studies the complex processes of fatty acid and lipid metabolism, NAD+ metabolism, iron metabolism and the metabolic responses to therapeutic agents. Synergy within this group is derived from interactions between biologists, x-ray crystallographers, geneticists, and biochemists to unravel the complicated metabolic processes common to tumor cells.