Scientific Focus: Cancer Biology and Biochemistry Program
of the Cancer Biology and Biochemistry (CBB) Program are to understand how
biochemistry shapes cancer cell origin and to translate these findings towards
human interventions, in collaboration with the Clinical Research Program. The
goals of the Program are achieved through the following Specific Aims to: 1)
Determine how specific biochemical pathways affect tumor initiation and development;
and 2) Develop novel therapeutic
strategies to improve cancer therapy.
three research themes within the Cancer Biology and Biochemistry Program:
- Redox Modulation
- Cellular Metabolism
- Genomic Maintenance
Modulation group has a common goal of understanding redox regulation and the
role of reactive oxygen species (ROS) in cancer and its response to various
in this thematic group work on ROS-mediated signaling, redox proteomic
profiling, the impact of radiation on cells and tumors, and structural biology.
Collaborations between biologists, biochemists, chemists, X-ray
crystallographers and physicists bring synergy to this group by providing
expertise that would otherwise be unavailable.
Cellular Metabolism group is focused on understanding how diverse metabolic
pathways contribute to the control of tumor growth.
of this thematic group studies the complex processes of fatty acid and lipid
metabolism, NAD+ metabolism, glucose metabolism and nanotechnology, and
glycolytic regulation. Synergy within this group is derived from interactions
between biologists, x-ray crystallographers, geneticists, and biochemists to
unravel the complicated metabolic processes common to tumor cells.
The DNA damage and Genomic Integrity group has a common goal of understanding the metabolism of DNA and how the processes maintain genomic integrity.
Members is this thematic group work on nucleotide metabolism,
RNA and DNA enzymatic metabolism, and nanodetection of genome scale
changes. Specific expertise includes damage and repair pathways in cancer, DNA processing by exonucleases, and the development of novel genotoxic agents. Collaborations between biologists, X-ray crystallographers, physicists and chemists provide synergistic enhancement to the scientific capabilities of this group.