Scientific Focus: Cancer Biology and Biochemistry Program

The Goals of the Cancer Biology and Biochemistry (CBB) Program are to understand how biochemistry shapes cancer cell origin and to translate these findings towards human interventions, in collaboration with the Clinical Research Program. The goals of the Program are achieved through the following Specific Aims to: 1) Determine how specific biochemical pathways affect tumor initiation and development; and 2) Develop novel therapeutic strategies to improve cancer therapy.

There are three research themes within the Cancer Biology and Biochemistry Program:

  • Redox Modulation
  • Cellular Metabolism
  • Genomic Maintenance

Redox Modulation

The Redox Modulation group has a common goal of understanding redox regulation and the role of reactive oxygen species (ROS) in cancer and its response to various therapeutic interventions.

Members in this thematic group work on ROS-mediated signaling, redox proteomic profiling, the impact of radiation on cells and tumors, and structural biology. Collaborations between biologists, biochemists, chemists, X-ray crystallographers and physicists bring synergy to this group by providing expertise that would otherwise be unavailable.

Cellular Metabolism

The Cellular Metabolism group is focused on understanding how diverse metabolic pathways contribute to the control of tumor growth.

Members of this thematic group studies the complex processes of fatty acid and lipid metabolism, NAD+ metabolism, glucose metabolism and nanotechnology, and glycolytic regulation. Synergy within this group is derived from interactions between biologists, x-ray crystallographers, geneticists, and biochemists to unravel the complicated metabolic processes common to tumor cells. 

Genomic Maintenance

The DNA damage and Genomic Integrity group has a common goal of understanding the metabolism of DNA and how the processes maintain genomic integrity.

Members is this thematic group work on nucleotide metabolism, RNA and DNA enzymatic metabolism, and nanodetection of genome scale changes. Specific expertise includes damage and repair pathways in cancer, DNA processing by exonucleases, and the development of novel genotoxic agents. Collaborations between biologists, X-ray crystallographers, physicists and chemists provide synergistic enhancement to the scientific capabilities of this group.

 

Last Updated: 01-29-2016
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