Cancer Genomics Shared Resource

Services We Provide

Tools and Instrumentation Used

    The CGSR has a modern infrastructure that includes:

    • Illumina NextSeq 500 NGS
    • Illumina MiSeq NGS
    • Affymetrix GeneAtlas Microarray System
    • Agilent 2100 Bioanalyzer
    • Custom scripts for data processing (R coding)

    Typical Experiments and Expertise

    Next Generation Sequencing (NGS)

    • RNAseq – gene expression profiling, gene fusion analysis, allele specific expression, splice variant detection, microRNA (miRNA) detection, long non-coding RNA (lncRNA) detection
    • Exome Sequencing – identification and validation of genetic variants (mutations, SNPs, insertion-deletions (InDels)
    • Whole genome sequencing – mutation detection, tumor profiling, denovo genome sequencing
    • Methylation sequencing – whole genome bisulfite sequencing, methylation enrichment (methylation binding protein)
    • ChIPseq – transcription factor binding site identification

    Microarray

    • Expression profiling – mRNA/miRNA/lncRNA profiling, tumor profiling, time course assays
    • Copy number variation (CNV) detection – tumor profiling, genetic association
    • SNP analysis – genome-wide association analysis
    • ChIP-chip – transcription factor binding site identification

    Bioinformatics

    • Data processing and quality control
    • Data normalization
    • Differential expression analysis
    • Mutational analysis
    • Clinico-genomic correlation analysis
    • Data visualization
    • Pathway enrichment analysis
    • Data mining and custom informatics

      How to Schedule Services

      See Sample Submission.

       

      Quick Reference

      Cancer Genomics Shared Resource
      Director
      Lance D. Miller, PhD

      336-716-6017

      ldmiller@wakehealth.edu

      Director
      Gregory Hawkins, PhD

      336-713-7511

      ghawkins@wakehealth.edu

      Technical Staff
      Lou Craddock

      336-713-5103

      lcraddoc@wakehealth.edu

      Wei Cui

      336-713-7141

      wcui@wakehealth.edu

      Jamie Haywood

      336-713-5103

      jhaywood@wakehealth.edu

      Dr. Jeff Chou

      336-713-1156

      jchou@wakehealth.edu

      Locations
      Hanes 4026/4028
      NRC 311/312
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      Last Updated: 03-18-2016
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      Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.

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