About Us: Prostate Cancer Center of Excellence
The large scope of activities represented by PCCOE members defies easy categorization. However, much of it falls in two broad areas:
Chemoprevention includes both the prevention of cancer and of recurrence. Chemopreventive activities focus on two agents, soy and vitamin J. Mark Cline, DVM, PhD, Department of Comparative Medicine, and colleagues are examining whether men who are supplemented with soy protein with isoflavones have a decreased risk of prostatic cell proliferation than men who are treated with placebo. This research, conducted within the Section on Comparative Medicine, is complemented by ongoing studies of soy on the behavioral and glandular function of macaque monkeys.
Progress in basic science and in epidemiology has facilitated the development of novel experimental therapies within the PCCOE. These approaches include the use of genetically engineered vesicular stomatitis virus to kill prostate cancer cells, an area in preclinical development by Doug Lyles, PhD and Miriam Ahmed, PhD. William Gmeiner, PhD, and colleagues are developing new drugs and novel strategies for drug delivery. Their discovery of novel polymeric form of fluoropyrimidines that are more potent and less toxic than conventional members of this class of drugs led to exciting developments in preclinical models. Progress in understanding intermediary metabolism of prostate cancer cells, such as the fatty acid synthesis pathway under investigation in the lab of Steven Kridel, PhD, is likely to identify new targets for novel therapies.