Synthetic Chemistry Shared Resource
The primary goal of the Synthetic Chemistry Shared Resource is to generate new molecular structures for the treatment of cancer. In addition, the facility hopes to stimulate collaboration and understanding between synthetic scientists and biological researchers. The facility also provides a focus point for interdisciplinary education on both the Reynolda and Medical School campuses for undergraduate and graduate students as well as postdoctoral researchers and faculty.
The Synthetic Chemistry Shared Resource directly supports the drug discovery/development theme of the Comprehensive Cancer Center of Wake Forest University’s basic research program. By its nature, this emerging shared resource stimulates collaboration and understanding between synthetic scientists and biological researchers. These collaborations bring together the required expertise to develop and mechanistically understand new cancer treatments at the molecular level.
The Synthetic Chemistry Shared Resource is housed in Salem Hall on the Reynolda Campus under the direction of S. Bruce King, PhD, director.
Services We Provide
The Synthetic Chemistry Shared Resource provides a number of resources to the Cancer Center and to Wake Forest University including:
- Literature searches for molecules of interest
- Literature searches for commercial availability of molecules of interest
- Consultation on synthesis/purification of molecules
- Preparation of new molecules for the treatment of cancer
S. Bruce King, PhD
Professor of Chemistry
15B Salem Hall
Department of Chemistry
Funded current projects include the preparation and structure-activity relationship of reserpine and its derivatives for their interaction with mismatch repair protein and the development and synthesis of carbohydrate-modified multi-walled carbon nanotubes for the ablation of cancer cells. Both of these projects are multidisciplinary in nature, bringing together scientists from a number of departments and are supported by National Institutes of Health (NIH) funding (R01CA128428-02S1, Torti, PI and NIH, R01CA129373, Salsbury, PI).
S. Bruce King