Alzheimer’s Disease Neuroimaging Initiative 2 (ADNI-2)

Short Study Name (acronym): ADNI-2

Long Name: Alzheimer’s Disease Neuroimaging Initiative 2

Investigators (list PI first): Kaycee Sink, MD

Funding Agency: ADCS through NIA

Funding Dates:  09/30/2010 – 08/31/2017

Research questions or aims: The study aims are focused on predictors, outcomes and clinical trial design, but fulfillment of these aims will add considerably to what is known about the basic neuroscience of AD in terms of progression and underlying mechanisms. Determine and define those biomarkers which best predict future cognitive decline and conversion to MCI/dementia at the various stages of the progression from normal cognition to dementia. Determine and define those biomarkers that best serve as outcome measures to quantify the rate of progress at the various stages from controls to dementia.  Improve clinical trials by developing various clinical trial protocol scenarios, which use clinical, cognitive, and biomarker measures as selection criteria, as covariates, and as outcome measures, with maximum statistical power to detect treatment effects. Such scenarios would be developed for subjects with dementia, with MCI, with mild symptomatology, subjects with significant memory concern but whose neuropsychological test performance is within the normal range, and normal healthy controls. As clinical trials are moving toward less or asymptomatic individuals, a new cohort, subjects with significant memory concerns have been included to address this shift.  Perform pathological examination on brains obtained by autopsy to validate the antemortum diagnoses.

Target population: Male and female age 55 - 90 years who meet the study criteria for early mild cognitive impairment and have a reliable study partner.

 Target # to enroll: 650 across the US and Canada

(Target) Dates of enrollment:  Closed

Types of assessments and questionnaires:  

Other data collected:

Study Website (if applicable): www.adni-info.org

Coordinator Contact Info:    Leslie Gordineer
                                                   lgordine@wakehealth.edu
                                                   336-713-8477

Last Updated: 02-18-2015
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