Cooperative Lifestyle Intervention Program (CLIP)
Long Name: Cooperative Lifestyle Intervention Program (CLIP)
The CLIP study is a 3-arm 18-month randomized, controlled trial of the effectiveness of physical activity, with and without weight loss, in the treatment of mobility disability in 288 older (60-79 years), overweight/obese men and women who have evidence of CVD or the metabolic syndrome. Participants are randomized to one of the 3 intervention groups: 1) a successful aging education control condition; 2) a group treatment program for physical activity; and 3) a lifestyle intervention that is designed to promote weight loss and increase physical activity. The primary aim of the study is to compare the effects of the three treatments on 18-month change in mobility disability, as assessed by the distance walked during a 400M walk test. A secondary aim is to test the effects of the interventions on change in: CVD risk factors (high-sensitivity C-reactive protein; lipid profiles; glucose and insulin; blood pressure), physical activity and dietary intake, body composition, and on health-related quality of life (HRQL). The public health relevance of the trial lies in the fact that the interventions will be delivered in conjunction with Cooperative Extension Centers.