Impact of an Exercise Program on Physical Function and Quality of Life in Aged Candidates for Renal Transplantation (PART)
Long Name:Impact of an Exercise Program on Physical Function and Quality of Life in Aged Candidates for Renal Transplantation (PART)
Although healthy older patients experience increased life expectancy after renal transplantation versus remaining on dialysis, outcomes such as the capacity to live independently and function well have not been studied. Given the poorer baseline health status in aging end-stage renal disease patients, rapid changes in health on dialysis, and the national organ shortage, it is increasingly important to identify factors predicting better outcome and devise strategies that will maximize the benefit of transplantation in older individuals. The physical capacity of older candidates for renal transplantation and their ability to sustain exercise programs are currently unknown. The primary goal of this study is to determine the feasibility of a physical activity intervention in older dialysis-dependent patients, assessing its effect on maintaining transplant candidacy and outcome after transplantation. This pilot study is a prospective, randomized, controlled trial. Enrollment will be offered to subjects = age 60 years who are on the renal transplant waiting list at WFBMC. Thirty subjects will be randomized to one of two groups: a home-based physical activity program designed to improve strength and aerobic capacity versus usual care (no intervention). Physical function, body composition and quality of life will be measured quarterly for 12 months.