Short Study Name (acronym):LIFE Cognition
Long Name:The LIFE Study is a Phase 3, multicenter randomized controlled trial designed to compare a moderate-intensity physical activity program to a successful aging health education program. The cognition portion of the study will determine if random program assignment will improve pre-specified measures of cognitive function and reduce the risk of the combined outcome of all-cause mild cognitive impairment or dementia.
Investigators (list PI first):
Jeff Williamson, MD
National Institutes on Aging
September 2009 – August 2015
Research questions or aims:
- Compared with random assignment to a successful aging program, random assignment to a long-term structured physical activity program improves pre-specified measures of cognitive function based on the Digit Symbol Test (DSST) and the Hopkins Verbal Learning Test (HVLT).
- Compared with random assignment to a successful aging program, random assignment to a long-term structured physical activity program reduces the risk of the combined outcome of all-cause mild cognitive impairment or dementia (MCI/D) and improves performance on a composite measure of cognitive function.
Sedentary males and females aged 70-89. Persons are eligible if they do not report a diagnosis of dementia or score <80 on the Modified Mini-Mental State (3MSE) Exam.
Target # to enroll:
Target Dates of enrollment:
February 2010 – December 2011
Types of assessments and questionnaires:
Hopkins Verbal Learning Test – Revised (HVLT-R), Modified Mini-Mental Status Exam (3MSE), Digit Symbol Substitution Test (DSST), Modified Rey-Osterreith Complex Figure (Rey-O), Flanker Test, The One-back Test, The Two-back Test, The Task-Switching Test
Other data collected:
Functional Assessment Questionnaire (FAQ)
Study Website (if applicable):https://www.thelifestudy.org
Project Manager Contact Info: