LIFE Cognition

Short Study Name (acronym):LIFE Cognition

Long Name:The LIFE Study is a Phase 3, multicenter randomized controlled trial designed to compare a moderate-intensity physical activity program to a successful aging health education program.  The cognition portion of the study will determine if random program assignment will improve pre-specified measures of cognitive function and reduce the risk of the combined outcome of all-cause mild cognitive impairment or dementia.

Investigators (list PI first):
Jeff Williamson, MD

Funding Agency:
National Institutes on Aging

Funding Dates:
September 2009 – August 2015

Research questions or aims:

  1. Compared with random assignment to a successful aging program, random assignment to a long-term structured physical activity program improves pre-specified measures of cognitive function based on the Digit Symbol Test (DSST) and the Hopkins Verbal Learning Test (HVLT).
  2. Compared with random assignment to a successful aging program, random assignment to a long-term structured physical activity program reduces the risk of the combined outcome of all-cause mild cognitive impairment or dementia (MCI/D) and improves performance on a composite measure of cognitive function.

Target population:
Sedentary males and females aged 70-89.  Persons are eligible if they do not report a diagnosis of dementia or score <80 on the Modified Mini-Mental State (3MSE) Exam.

Target # to enroll:
1600 participants

Target Dates of enrollment:
February 2010 – December 2011

Types of assessments and questionnaires:
Hopkins Verbal Learning Test – Revised (HVLT-R), Modified Mini-Mental Status Exam (3MSE), Digit Symbol Substitution Test (DSST), Modified Rey-Osterreith Complex Figure (Rey-O), Flanker Test, The One-back Test, The Two-back Test, The Task-Switching Test

Other data collected:
Functional Assessment Questionnaire (FAQ)

Study Website (if applicable):https://www.thelifestudy.org

Project Manager Contact Info:
Nancy Woolard

Email: nwoolard@wakehealth.edu
Phone:336-713-8585

Last Updated: 12-05-2014
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