Molecular Endocrinology and Hypertension

Bridget Brosnihan, PhD


Dr. Brosnihan’s academic qualifications reflect a professional trajectory characterized by novel and significant contributions to the understanding of the neuro-hormonal mechanisms participating in the regulation of cardiovascular function and the role that estrogen plays in the modulation of neural and hormonal mechanisms regulating arterial pressure. Dr. Brosnihan has been a major contributor to the discovery and understanding of the actions of angiotensin-(1-7) [Ang-(1-7)], a novel peptide of the renin-angiotensin system that opposes the actions of Ang II. Her studies were responsible for the original demonstration that Ang-(1-7) regulates vasopressin release and acts as a powerful vasodilator of the coronary circulation through the release of nitric oxide. While at WFSM, Dr. Brosnihan initiated a novel and highly productive effort on the role of estrogen in the regulation of the activity of angiotensin converting enzyme and angiotensin peptides; studies which began to unravel the mechanisms by which estrogen influences blood pressure and displays vasculo-protective functions. This led to major contributions including her discovery that ACE2 and Ang-(1-7) were up-regulated in normal pregnancy and down-regulated in preeclampsia and the characterization of the local RAS in the chorionic villi and maternal uterus in preeclampsia. She has brought national and international recognition to clinical research efforts in the assays of the angiotensin system hormones and enzymes, has participated in multiple clinical, pharmaceutical and NIH-sponsored studies, and facilitated the scientific efforts of many other faculty members whose research depended upon the availability of assays for measurements of inflammatory markers, cytokines, and growth factors. She has been certified since 1996 as a Board-certified High Complexity Director of Clinical Laboratories by the American Board of Bioanalysis.

 

Contact:
Hypertension and Vascular Research Center Core Laboratory
Wake Forest School of Medicine
Hanes Bldg., 6th Floor, Rooms 6034 & 6035
Medical Center Blvd
Winston-Salem, NC 27157
Tel: (336) 716-3812
Fax: (336) 716-2456 

Quick Reference

Hypertension and Vascular Research Center

Phone: 336-716-5819
FAX: 336-716-2456
Clinic Appointments:
336-716-2949
Hemodynamic Diagnostic Lab Scheduling
336-716-9423

Location
Hypertension & Vascular Research Center
Wake Forest School of Medicine, 6 Hanes
Medical Center Boulevard, Winston-Salem, NC
27157
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Last Updated: 06-23-2014
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